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[8] [9] It was developed as a recombinant protein (rhIL-11) as the drug substance oprelvekin. The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, [6] and encodes a 23 kDa protein. IL-11 is a member of the IL-6-type cytokine family, distinguished based on their use of the common co-receptor gp130.
IL-11 is a member of a family of human growth factors and is being produced in the bone marrow of healthy adults. Synonyms are: AGIF; Adipogenesis inhibitory factor; Interleukin-11 precursor. Oprelvekin is produced in Escherichia coli (E. coli) by recombinant DNA technology.
The problem began in 2012, when the process for making tetrazole, a chemical intermediate in the production of various angiotensin II inhibitor medications for hypertension (popularly known by their common drug name suffix "sartan") was changed by generic drug manufacturers in favor of several cheaper and more efficient processes.
Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene. [5] Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which ...
IL-11 or IL 11 can refer to: Interleukin 11; Illinois's 11th congressional district; Illinois Route 11 This page was last edited on 28 December 2019, at 20:09 ...
China is sending 11 swimmers embroiled in a doping scandal to the Paris 2024 Olympics.. Among the 31-member swim roster it released Tuesday, the Chinese Swimming Association named almost a dozen ...
Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis, systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, giant cell arteritis, cytokine release syndrome, COVID‑19, and systemic sclerosis-associated interstitial lung disease (SSc-ILD).
The independent misconduct of two chemists at the William A. Hinton State Laboratory Institute in Massachusetts caused the drug lab to be shut down and tens of thousands of criminal convictions for drug possession to be overturned. Annie Dookhan admitted to faking test results and adulterating samples to make them consistent with her desired ...