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The Ca 2+ concentration of the vacuole may reach millimolar levels. The most striking use of Ca 2+ ions as a structural element in algae occurs in the marine coccolithophores, which use Ca 2+ to form the calcium carbonate plates, with which they are covered. Calcium is needed to form the pectin in the middle lamella of newly formed cells.
In myocytes (muscle cells) Ca 2+ is normally sequestered (isolated) in a specialized form of endoplasmic reticulum (ER) called sarcoplasmic reticulum (SR). It is a Ca 2+ ATPase that transfers Ca 2+ from the cytosol of the cell to the lumen of the SR at the expense of ATP hydrolysis during muscle relaxation. In the skeletal muscles the calcium ...
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The Ca 2+ in the myoplasm will diffuse to Ca 2+ regulator sites on the thin filaments. This leads to the actual contraction of the muscle. [15] Contractions of smooth muscle fiber are dependent on how a Ca 2+ influx occurs. When a Ca 2+ influx occurs, cross bridges form between myosin and actin leading to the
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E1⋅2Ca 2+ - cytoplasmic gate open, free Ca 2+ ion exchange occurs between bound ions and those in cytoplasm, closed configuration of N, P, A domains broken, exposing catalytic site E1⋅ ATP - ATP binds and links N to P , P bends, N contacts A , A causes M1 helix to pull up, closes cytoplasmic gate, bound Ca 2+ occluded in transmembrane
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When calcium ions (Ca 2+) are depleted from the endoplasmic reticulum (a major store of Ca 2+) of mammalian cells, the CRAC channel is activated to slowly replenish the level of calcium in the endoplasmic reticulum. The Ca 2+ Release-activated Ca 2+ (CRAC) Channel (CRAC-C) Family (TC# 1.A.52) is a member of the Cation Diffusion Facilitator (CDF ...
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