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Hypothermia can set in when the core temperature drops to 35 °C (95 °F). [2] Hyperthermia can set in when the core body temperature rises above 37.5–38.3 °C (99.5–100.9 °F). [ 3 ] [ 4 ] Humans have adapted to living in climates where hypothermia and hyperthermia were common primarily through culture and technology, such as the use of ...
The normal human body temperature is often stated as 36.5–37.5 °C (97.7–99.5 °F). [8] [9] In adults a review of the literature has found a wider range of 33.2–38.2 °C (91.8–100.8 °F) for normal temperatures, depending on the gender and location measured. [14]
As in other mammals, human thermoregulation is an important aspect of homeostasis. In thermoregulation, body heat is generated mostly in the deep organs, especially the liver, brain, and heart, and in contraction of skeletal muscles. [1] Humans have been able to adapt to a great diversity of climates, including hot humid and hot arid.
Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different. A thermoconforming organism, by contrast, simply adopts the surrounding temperature as its own body temperature, thus avoiding the need for internal thermoregulation.
The human body maintains a core body temperature at around 37 °C or 98.6 °F through mechanisms controlled by the thermoregulatory center within the hypothalamus.When the body is exposed to high ambient temperatures, intense physical exertion, or both, the thermoregulatory center will initiate several processes to dissipate more heat: [9] [11] [12]
This response is due to the energy required to maintain a relatively constant body temperature above ambient temperature by controlling heat loss and heat gain. [1] The degree of this response depends not only on the species, but also on the levels of insulative and metabolic adaptation. [ 2 ]
The internal thermoregulation process is one aspect of homeostasis: a state of dynamic stability in an organism's internal conditions, maintained far from thermal equilibrium with its environment. If the body is unable to maintain a normal human body temperature and it increases significantly above normal, a condition known as hyperthermia occurs.
The cannabinoid receptor type 1, located at the presynaptic neuron, is a receptor that can stop stressful neurotransmitter release to the postsynaptic neuron; it is activated by endocannabinoids such as anandamide (N-arachidonoylethanolamide) and 2-arachidonoylglycerol via a retrograde signaling process in which these compounds are synthesized ...