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Quantitative genetics is the study of quantitative traits, which are phenotypes that vary continuously—such as height or mass—as opposed to phenotypes and gene-products that are discretely identifiable—such as eye-colour, or the presence of a particular biochemical.
In quantitative genetics, Q ST is a statistic intended to measure the degree of genetic differentiation among populations with regard to a quantitative trait. It was developed by Ken Spitze in 1993. [1] Its name reflects that Q ST was intended to be analogous to the fixation index for a single genetic locus (F ST).
Genetic architecture is an overall explanation of all the genetic factors that play a role in a complex trait and exists as the core foundation of quantitative genetics. With the use of mathematical models and statistical analysis, like GWAS, researchers can determine the number of genes affecting a trait as well as the level of influence each ...
In it, Fisher puts forward the "infinitesimal model", a genetics conceptual model showing that continuous variation amongst phenotypic traits could be the result of Mendelian inheritance. The paper also contains the first use of the statistical term variance. [2] It is considered the foundation of quantitative genetics. [3]
The infinitesimal model, also known as the polygenic model, is a widely used statistical model in quantitative genetics and in genome-wide association studies.Originally developed in 1918 by Ronald Fisher, it is based on the idea that variation in a quantitative trait is influenced by an infinitely large number of genes, each of which makes an infinitely small (infinitesimal) contribution to ...
A quantitative trait locus (QTL) is a locus (section of DNA) that correlates with variation of a quantitative trait in the phenotype of a population of organisms. [1] QTLs are mapped by identifying which molecular markers (such as SNPs or AFLPs ) correlate with an observed trait.
Fisher founded quantitative genetics, [16] [17] and together with J. B. S. Haldane and Sewall Wright, is known as one of the three principal founders of population genetics. [18] Fisher outlined Fisher's principle , the Fisherian runaway , the sexy son hypothesis theories of sexual selection , parental investment , and also pioneered linkage ...
In multivariate quantitative genetics, a genetic correlation (denoted or ) is the proportion of variance that two traits share due to genetic causes, [1] [2] [3] ...
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