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  2. Noradrenergic and specific serotonergic antidepressant

    en.wikipedia.org/wiki/Noradrenergic_and_specific...

    Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1] They act by antagonizing the α 2 -adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C , [ 1 ] but also 5-HT 3 , [ 1 ] 5-HT 6 , and/or 5-HT 7 in some cases.

  3. Mirtazapine - Wikipedia

    en.wikipedia.org/wiki/Mirtazapine

    Mirtazapine is a very strong H 1 receptor antagonist and, as a result, it can cause powerful sedative and hypnotic effects. [11] A single 15 mg dose of mirtazapine to healthy volunteers has been found to result in over 80% occupancy of the H 1 receptor and to induce intense sleepiness. [92]

  4. List of antidepressants - Wikipedia

    en.wikipedia.org/wiki/List_of_antidepressants

    This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.

  5. Management of depression - Wikipedia

    en.wikipedia.org/wiki/Management_of_depression

    A 2012 meta-analysis found that zinc supplementation as an adjunct to antidepressant drug treatment significantly lowered depressive symptom scores of depressed patients. [74] The potential mechanisms underlying the association between low serum zinc and depression remain unclear, but may involve the regulation of neurotransmitter, endocrine ...

  6. Serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Serotonin_reuptake_inhibitor

    For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, is an SRI but not an SSRI. SRIs are used predominantly as antidepressants (e.g., SSRIs, SNRIs , and TCAs ), though they are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating ...

  7. Management of schizophrenia - Wikipedia

    en.wikipedia.org/wiki/Management_of_schizophrenia

    The result of stopping smoking can lead to an increased concentration of the antipsychotic that may result in toxicity, so that monitoring of effects would need to take place with a view to decreasing the dosage; many symptoms may be noticeably worsened, and extreme fatigue, and seizures are also possible with a risk of relapse.

  8. Serotonin antagonist and reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Serotonin_antagonist_and...

    Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act by antagonizing serotonin receptors such as 5-HT 2A and inhibiting the reuptake of serotonin, norepinephrine, and/or dopamine. Additionally, most also antagonize α 1-adrenergic receptors.

  9. Treatment-resistant depression - Wikipedia

    en.wikipedia.org/wiki/Treatment-resistant_depression

    Increasing the dosage of an antidepressant is a common strategy to treat depression that does not respond after adequate treatment duration. Practitioners who use this strategy will usually increase the dose until the person reports intolerable side effects, symptoms are eliminated, or the dose is increased to the limit of what is considered ...

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