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Lutetium (177 Lu) oxodotreotide or 177 Lu dotatate, brand name Lutathera, is a chelated complex of a radioisotope of the element lutetium with dotatate, used in peptide receptor radionuclide therapy. Specifically, it is used in the treatment of cancers which express somatostatin receptors. [5] It is a radiolabeled somatostatin analog. [3] [6] [7]
DOTA-TATE can be reacted with the radionuclides gallium-68 (T 1/2 = 68 min), lutetium-177 (T 1/2 = 6.65 d) and copper-64 (T 1/2 = 12.7 h) to form radiopharmaceuticals for positron emission tomography (PET) imaging or radionuclide therapy. 177 Lu DOTA-TATE therapy is a form of peptide receptor radionuclide therapy (PRRT) which targets ...
Radiation from lutetium (177 Lu) oxodotreotide can cause damage when the medicine passes through tubules in the kidney. [45] Arginine/lysine can be used to reduce renal radiation exposure during peptide receptor radionuclide therapy with lutetium ( 177 Lu) oxodotreotide.
Lutetium (177Lu) oxodotreotide; Lutetium (177Lu) vipivotide tetraxetan; Lutetium phthalocyanine; M. Motexafin lutetium This page was last edited on 4 January 2022 ...
Forty radioisotopes have been characterized, with the most stable, besides 176 Lu, being 174 Lu with a half-life of 3.31 years, and 173 Lu with a half-life of 1.37 years. All of the remaining radioactive isotopes have half-lives that are less than 9 days, and the majority of these have half-lives that are less than half an hour.
Skeletal formula of lutetium (177 Lu) oxodotreotide (177Lu-DOTATATE, Lutathera). Date: 2 November 2020: Source: ... Lutetium Lu 177 dotatate; Usage on te.wikipedia.org
Lutetium compounds are compounds formed by the lanthanide metal lutetium (Lu). In these compounds, lutetium generally exhibits the +3 oxidation state, such as LuCl 3, Lu 2 O 3 and Lu 2 (SO 4) 3. [1] Aqueous solutions of most lutetium salts are colorless and form white crystalline solids upon drying, with the common exception of the iodide.
177 Lu-DOTA-TATE: gastroenteropancreatic neuroendocrine tumors (GEP-NETs) IV In-vivo: Nitrogen-13. 13 N is a positron emitter. Name Investigation