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The primary function of keratinocytes is the formation of a barrier against environmental damage by heat, UV radiation, dehydration, pathogenic bacteria, fungi, parasites, and viruses.
The keratinocytes are the primary cell of the epidermis. They originate in the deepest layer of the epidermis- stratum basale and continue to the outer most layer - stratum corneum. In the basal layer, the keratinocytes contain a number of cells including : free ribosomes, small golgi apparatus, mitochondria, intermediate filaments and the ...
The main function of the keratinocytes is to form a strong barrier against pathogens, UV radiation, and harmful chemicals, while also minimizing the loss of water and heat from the body.
They are used to research a number of phenomena of the skin including epidermal acidification, DNA degradation, fatty acid metabolism and transport, local immune responses, cell regeneration, stem cell differentiation and tumor formation.
Function. Keratinocytes are highly specialized. They play an essential role in protection, as they form a tight barrier that prevents foreign substances from entering the body, while minimizing the loss of moisture, heat, and other constituents.
Keratinocytes act as sentinels, continuously monitoring changes in the environment, and, through microbial sensing, stretch, or other physical stimuli, can initiate a broad range of inflammatory responses via secretion of various cytokines, chemokines, and growth factors.
Most of the cells in the epidermis are keratinocytes. They originate from cells in the deepest layer of the epidermis called the basal layer. New keratinocytes slowly migrate up toward the surface of the epidermis.
Keratinocytes are useful for scientific applications including the study of growth factor behavior and wound healing. Non-melanoma skin cancers such as basal cell carcinoma and squamous cell carcinoma arise from keratinocytes, which provide the functional epidermal barrier.
Keratinocytes form the outermost barrier of the skin, and sense changes in barrier integrity, intrusion of microbial components and stress molecules. Thus, they act as sentinels that continuously communicate the status of the organ to the cutaneous immune system.
The main function of keratinocytes is to produce keratin, which is primarily a structural protein. There are 54 genes that code for keratin that is divided into two families: Type 1 (acidic) and Type 2 (basic).