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The endoplasmic reticulum is found in most eukaryotic cells and forms an interconnected network of flattened, membrane-enclosed sacs known as cisternae (in the RER), and tubular structures in the SER. The membranes of the ER are continuous with the outer nuclear membrane. The endoplasmic reticulum is not found in red blood cells, or spermatozoa.
The ER is made up of flattened sacs and branching tubules that are thought to interconnect, so that the ER membrane forms a continuous sheet enclosing a single internal space. This highly convoluted space is called the ER lumen and is also referred to as the ER cisternal space.
A desmotubule is an endomembrane derived structure of the plasmodesmata that connects the endoplasmic reticulum of two adjacent plant cells. [1] [2] The desmotubule is not actually a tubule but a compact, cylindrical segment of the ER that is found within the larger tubule structure of the plasmodesmata pore. [3]
The endoplasmic-reticulum–Golgi intermediate compartment (ERGIC) is an organelle in eukaryotic cells. This compartment mediates transport between the endoplasmic reticulum (ER) and Golgi complex , facilitating the sorting of cargo. [ 1 ]
ER retention refers to proteins that are retained in the endoplasmic reticulum, or ER, after folding; these are known as ER resident proteins. Protein localization to the ER often depends on certain sequences of amino acids located at the N terminus or C terminus. These sequences are known as signal peptides, molecular signatures, or sorting ...
Late endosomes, also known as MVBs, are mainly spherical, lack tubules, and contain many close-packed intraluminal vesicles. Markers include RAB7, RAB9, and mannose 6-phosphate receptors. [ 10 ] In addition to this, the late endosomal membrane (and consequently the lysosome) contains a peculiar and unique lipid named BMP or LBPA, which is not ...
The 2013 Nobel Prize in Physiology or Medicine was shared by James Rothman, Randy Schekman and Thomas Südhof for their roles in elucidating (building upon earlier research, some of it by their mentors) the makeup and function of cell vesicles, especially in yeasts and in humans, including information on each vesicle's parts and how they are assembled.
The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis.The collecting duct participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone).