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HHC-acetate (Hexahydrocannabinol-O-acetate, HHC-O) is a semi-synthetic cannabinoid derivative which has been marketed since around 2022. [ 1 ] [ 2 ] It is believed to be made in a three step process from cannabidiol extracted from hemp . [ 3 ]
Hexahydrocannabinol (HHC) is a hydrogenated derivative of tetrahydrocannabinol (THC). It is a naturally occurring phytocannabinoid that has rarely been identified as a trace component in Cannabis sativa, [1] [2] but can also be produced synthetically by firstly acid cyclization of cannabidiol and then hydrogenation of tetrahydrocannabinol.
A store selling synthetic cannabinoids in Riga in 2012 JWH-018, JWH-073, CP 47,497 (and its homologues), and HU-210, as well as leonotis leonurus , have been all banned in Latvia since 2005. [ 128 ] After the first confirmed lethal case from the use of legal drugs in late 2013, parliament significantly increased the number of temporarily banned ...
In October 2021, researchers at Johns Hopkins University reported over 2,000 unknown chemicals in the vape clouds that they tested from Vuse, Juul, Blu and Mi-Salt vape devices. [ 171 ] In 2019–2020, there was an outbreak of vaping-related lung illness in the US and Canada, primarily related to vaping THC with vitamin E acetate .
Four stereoisomers of 8-OH-HHC arise from C8-hydroxylation of hexahydrocannabinol. There are four possible 8-OH-HHC metabolites arising from naturally derived HHCs: cis-and trans-8-OH-9α-HHC & cis-and trans-8-OH-9β-HHC. All four have been prepared synthetically to probe stereochemical effects on cannabinoid biological activity. [5]
Hexahydrocannabihexol (HHCH) is a semi-synthetic cannabinoid derivative. It was first synthesised by Roger Adams in 1942 and found to be more potent than either the pentyl or heptyl homologues, or the unsaturated tetrahydrocannabinol analogue.
The volume of vapor created by e-cigarette devices in 2012 declined with vaping. [1] Thus, to create the same volume of vapor increasing puff force is needed. [1] Later-generation e-cigarettes with concentrated nicotine liquids may deliver nicotine at levels similar to traditional cigarettes. [45]
Δ-8-tetrahydrocannabinol (delta-8-THC, [a] Δ 8-THC) is a psychoactive cannabinoid found in the cannabis plant. [1] It is an isomer of delta-9-tetrahydrocannabinol (delta-9-THC, Δ 9-THC), the compound commonly known as THC, with which it co-occurs in hemp; natural quantities of ∆ 8-THC found in hemp are low.