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The systematic name of this enzyme class is benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating). Other names in common use include benzene hydroxylase , and benzene dioxygenase . Biological role
The catechol dioxygenases, some of the most well-studied dioxygenase enzymes, use dioxygen to cleave a carbon-carbon bond of an aromatic catechol ring system. [4] Catechol dioxygenases are further classified as being “extradiol” or “intradiol,” and this distinction is based on mechanistic differences in the reactions (figures 1 & 2).
Alkaptonuria is a rare inherited genetic disease which is caused by a mutation in the HGD gene for the enzyme homogentisate 1,2-dioxygenase (EC 1.13.11.5); if a person inherits an abnormal copy from both parents (it is a recessive condition), the body accumulates an intermediate substance called homogentisic acid in the blood and tissues.
Catechol dioxygenases are metalloprotein enzymes that carry out the oxidative cleavage of catechols.This class of enzymes incorporate dioxygen into the substrate.Catechol dioxygenases belong to the class of oxidoreductases and have several different substrate specificities, including catechol 1,2-dioxygenase (EC 1.13.11.1), catechol 2,3-dioxygenase (EC 1.13.11.2), and protocatechuate 3,4 ...
The two enzymes were identified to be a part of two separate catechol dioxygenase families: 1,2-CTD was classified as an intradiol dioxygenase while 2,3-CTD was classified as an extradiol dioxygenase. The two enzymes can be distinguished based on their reaction products and cofactors. 1,2-CTD uses Fe 3+ as a cofactor to cleave the carbon-carbon ...
On the week ending 20 April, nearly two-thirds of the over 2,400 deaths that occurred in England and Wales were in males. Coronavirus: Men may have more of a 'dangerous' enzyme Skip to main content
The first four seem to be involved in the hydroxylation of toluene to benzyl alcohol. CYP2E1 seems to be the primary enzyme in the hydroxylation of toluene, accounting for roughly 44% of toluene metabolism; [1] however, there is a great deal of ethnic variability, in the Finnish population for example the primary enzyme is CYP2B6.
Benzene was also detected in Proactiv, PanOxyl, Walgreens' acne soap bar and Walmart's Equate Beauty acne cream among others, according to Valisure. Cancer-causing chemical found in Clinique ...