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Health officials remain perplexed by mysterious cases of severe liver damage in hundreds of young children around the world. The best available evidence points to a fairly common stomach bug that ...
Liver diseases, including conditions such as non-alcoholic fatty liver disease (NAFLD), alcohol-related liver disease (ALD), and viral hepatitis, are significant public health concerns worldwide. In the United States, NAFLD is the most common chronic liver condition, affecting approximately 24% of the population, with the prevalence rising due ...
Liver transplantation is an option for those children whose liver function and symptoms fail to respond to a Kasai operation. [29] Recent large-scale studies by Davenport et al. (Annals of Surgery, 2008) show that the age of the patient is not an absolute clinical factor affecting prognosis. The influence of age differs according to the disease ...
Autoimmune hepatitis, formerly known as lupoid hepatitis, plasma cell hepatitis, or autoimmune chronic active hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells, causing the liver to be inflamed.
The Centers for Disease Control and Prevention is asking physicians nationwide to be on the lookout for unusual cases of severe hepatitis in children. CDC issues alert for rare liver damage in ...
The severity of the disorder can vary within the same family, with symptoms ranging from so mild as to go unnoticed, to severe heart and/or liver disease that requires transplantation. [6] It is uncommon, but Alagille syndrome can be a life-threatening disease with a mortality rate of 10%. [7]
Older children or adults generally present with a wide range of signs and symptoms that overlap with other disorders. [5] They may have diarrhoea, stomach pain, vomiting, or poor growth, a sign of malabsorption. They may have signs of bile duct problems, like itchiness, jaundice, pale stool, or dark urine. Their feces may be excessively greasy.
The disease is typically progressive, leading to fulminant liver failure and death in childhood, in the absence of liver transplantation. Hepatocellular carcinoma may develop in PFIC-2 at a very early age; even toddlers have been affected. [citation needed]