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Lactic acidosis refers to the process leading to the production of lactate by anaerobic metabolism. It increases hydrogen ion concentration tending to the state of acidemia or low pH. The result can be detected with high levels of lactate and low levels of bicarbonate. This is usually considered the result of illness but also results from ...
Septic shock is a subclass of distributive shock, a condition in which abnormal distribution of blood flow in the smallest blood vessels results in inadequate blood supply to the body tissues, resulting in ischemia and organ dysfunction. Septic shock refers specifically to distributive shock due to sepsis as a result of infection.
Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. [4][7] This initial stage of sepsis is followed by suppression of the immune system. [8] Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion. [1]
Hypovolemic shock is a form of shock caused by severe hypovolemia (insufficient blood volume or extracellular fluid in the body). [1][2] It can be caused by severe dehydration or blood loss. [3][2] Hypovolemic shock is a medical emergency; if left untreated, the insufficient blood flow can cause damage to organs, leading to multiple organ failure.
Anaerobic glycolysis. Anaerobic glycolysis is the transformation of glucose to lactate when limited amounts of oxygen (O 2) are available. [1] This occurs in health as in exercising and in disease as in sepsis and hemorrhagic shock. [1] providing energy for a period ranging from 10 seconds to 2 minutes. During this time it can augment the ...
Increased demand occurs, for example, with high intensity exercise such as sprinting. Inadequate supply occurs, for example, with hypoperfusion as occurs in hemorrhagic shock. A rise in lactate out of proportion to the level of pyruvate , e.g., in mixed venous blood, is termed "excess lactate", and is an indicator of anaerobic glycolysis ...
Ringer's lactate solution (RL), also known as sodium lactate solution, Lactated Ringer's (LR), and Hartmann's solution, is a mixture of sodium chloride, sodium lactate, potassium chloride, and calcium chloride in water. [1] It is used for replacing fluids and electrolytes in those who have low blood volume or low blood pressure. [2]
High anion gap metabolic acidosis is a form of metabolic acidosis characterized by a high anion gap (a medical value based on the concentrations of ions in a patient's serum). Metabolic acidosis occurs when the body produces too much acid, or when the kidneys are not removing enough acid from the body. Several types of metabolic acidosis occur ...