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Choriocarcinoma is a malignant, trophoblastic [1] cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs. It is characterized by early hematogenous spread to the lungs.
The choriocarcinoma has 2 significant subtypes including gestational and non-gestational and they are differentiated by their different biological feature and prognosis. [4] Signs and symptoms of GTN will appear vary from person to person and depending upon the type of the disease.
Gestational choriocarcinoma is a form of gestational trophoblastic neoplasia, which is a type of gestational trophoblastic disease (GTD), that can occur during pregnancy. It is a rare disease where the trophoblast , a layer of cells surrounding the blastocyst , undergoes abnormal developments, leading to trophoblastic tumors .
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Diagram showing stage 3 choriocarcinoma. Date: 30 July 2014 (released by CRUK) Source: Original email from CRUK: Author: Cancer Research UK: Permission (Reusing this file) This image has been released as part of an open knowledge project by Cancer Research UK. If re-used, attribute to Cancer Research UK / Wikimedia Commons
A micrograph showing a choriocarcinoma spread to the lung [13] Choriocarcinomas are exceptionally rare which account for 2.1%-3.4% of all OGCTs. [ 14 ] Under gross examination, the syncytiotrophoblast cells are aligned in a plexiform arrangement with the mononucleated cytotrophoblast cells surrounding the foci of the hemorrhage. [ 1 ]
The rise of colorectal cancer among people under 50 in the U.S. has had experts worried for years — and new research shows how the ominous trend has spread globally.
Notably, complete hydatidiform moles account for 50% of all cases of choriocarcinoma. Molar pregnancies are relatively rare complications of pregnancy, occurring in approximately 1 in 1,000 pregnancies in the United States, while in Asia, the rates are considerably higher, reaching up to 1 in 100 pregnancies in countries like Indonesia.