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Choriocarcinoma is a malignant, trophoblastic [1] cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs. It is characterized by early hematogenous spread to the lungs.
Gestational choriocarcinoma is a form of gestational trophoblastic neoplasia, which is a type of gestational trophoblastic disease (GTD), that can occur during pregnancy. It is a rare disease where the trophoblast , a layer of cells surrounding the blastocyst , undergoes abnormal developments, leading to trophoblastic tumors .
The choriocarcinoma has 2 significant subtypes including gestational and non-gestational and they are differentiated by their different biological feature and prognosis. [4] Signs and symptoms of GTN will appear vary from person to person and depending upon the type of the disease.
Although choriocarcinoma is a highly malignant tumour and a life-threatening disease, it is very sensitive to chemotherapy. Virtually all women with non-metastatic disease are cured and retain their fertility; the prognosis is also very good for those with metastatic (spreading) cancer, in the early stages, but fertility may be lost.
Symptoms begin 12 to 48 hours after exposure to the virus and last for about 1 to 3 days. Even after recovering, infected individuals can be contagious for two more weeks.
A micrograph showing a choriocarcinoma spread to the lung [13] Choriocarcinomas are exceptionally rare which account for 2.1%-3.4% of all OGCTs. [ 14 ] Under gross examination, the syncytiotrophoblast cells are aligned in a plexiform arrangement with the mononucleated cytotrophoblast cells surrounding the foci of the hemorrhage. [ 1 ]
Angiomatous (vascular) type : This is the most common type of choriocarcinoma. It is distinguished by the presence of numerous small blood vessels. Degenerative type : This is the mature type with degenerative changes. Each type is believed to represent a phase of tumor development. Chorioangioma has no malignant potential.
Here are the most common symptoms of the 2024 XEC variant, per a doctor. ... Here Are The Symptoms To Look For, According To An Infectious Disease Doctor. Korin Miller. December 23, 2024 at 10:59 AM.