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  2. Single-strand DNA-binding protein - Wikipedia

    en.wikipedia.org/wiki/Single-strand_DNA-binding...

    Single-stranded DNA is produced during all aspects of DNA metabolism: replication, recombination, and repair. As well as stabilizing this single-stranded DNA, SSB proteins bind to and modulate the function of numerous proteins involved in all of these processes. Active E. coli SSB is composed of four identical 19 kDa subunits. Binding of single ...

  3. Single-stranded binding protein - Wikipedia

    en.wikipedia.org/.../Single-stranded_binding_protein

    In ICP8, the herpes simplex virus (HSV-1) single-strand DNA-binding protein (ssDNA-binding protein (SSB)), the head consists of the eight alpha helices.The front side of the neck region consists of a five-stranded beta-sheet and two alpha helices, whereas the back side is a three-stranded beta-sheet The shoulder part of the N-terminal domain contains an alpha-helical and beta-sheet region. [1]

  4. Replication protein A - Wikipedia

    en.wikipedia.org/wiki/Replication_protein_A

    Steps in DNA synthesis, with RPA shown. Replication protein A (RPA) is the major protein that binds to single-stranded DNA (ssDNA) in eukaryotic cells. [1] [2] In vitro, RPA shows a much higher affinity for ssDNA than RNA or double-stranded DNA. [3]

  5. Poly (ADP-ribose) polymerase - Wikipedia

    en.wikipedia.org/wiki/Poly_(ADP-ribose)_polymerase

    The main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair.

  6. DNA-binding protein - Wikipedia

    en.wikipedia.org/wiki/DNA-binding_protein

    A distinct group of DNA-binding proteins are the DNA-binding proteins that specifically bind single-stranded DNA. In humans, replication protein A is the best-understood member of this family and is used in processes where the double helix is separated, including DNA replication, recombination and DNA repair. [18]

  7. DNA replication - Wikipedia

    en.wikipedia.org/wiki/DNA_replication

    To prevent this, single-strand binding proteins bind to the DNA until a second strand is synthesized, preventing secondary structure formation. [ 43 ] Double-stranded DNA is coiled around histones that play an important role in regulating gene expression so the replicated DNA must be coiled around histones at the same places as the original DNA ...

  8. These are the top 100+ gifts of 2024, according to Amazon - AOL

    www.aol.com/lifestyle/top-100-gifts-2024-amazon...

    Looking for gifting inspiration? Amazon is tracking the year's top 100 gifts, from cozy weighted blankets to chic mini blenders. Here are our favorites.

  9. Replisome - Wikipedia

    en.wikipedia.org/wiki/Replisome

    The combination of template DNA and primer RNA is referred to as 'A-form DNA' and it is thought that clamp loading replication proteins (helical heteropentamers) want to associate with A-form DNA because of its shape (the structure of the major/minor groove) and chemistry (patterns of hydrogen bond donors and acceptors).

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