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Osteolytic lesion at the bottom of the radius, diagnosed by a darker section that indicates a loss of bone density. An osteolytic lesion (from the Greek words for "bone" (ὀστέον), and "to unbind" (λύειν)) is a softened section of a patient's bone formed as a symptom of specific diseases, including breast cancer and multiple myeloma.
Typically, osteolytic metastases are more aggressive than osteoblastic metastases, which have a slower course. Regardless of the phenotype, bone metastases commonly show osteoclast proliferation and hypertrophy. [5] Primary tumors. Osteoblastic lesions [6] Prostate cancer; Carcinoid; Small cell lung cancer; Hodgkin lymphoma; Medulloblastoma ...
Osteolysis is an active resorption of bone matrix by osteoclasts and can be interpreted as the reverse of ossification.Although osteoclasts are active during the natural formation of healthy bone the term "osteolysis" specifically refers to a pathological process.
A brain metastasis is a cancer that has metastasized (spread) to the brain from another location in the body and is therefore considered a secondary brain tumor. [ 1 ] [ 2 ] The metastasis typically shares a cancer cell type with the original site of the cancer. [ 3 ]
Multiple myeloma is a type of cancer involving malignant plasma cells, called myeloma cells, within the bone marrow. [45] Multiple myeloma is associated with osteolytic bone lesions as the usually high levels of OPG in the bone marrow are diminished resulting in increased osteoclastic absorption. [16]
Lesions are often classified by their tissue types or locations. For example, a "skin lesion" or a "brain lesion" are named for the tissue where they are found.If there is an added significance to regions within the tissue—such as in neural injuries where different locations correspond to different neurological deficits—they are further classified by location.
A CT of the brain revealed a lytic lesion in the left temporal bone (right side of image), and petrous temporal bones involving the mastoid segment of the facial nerve canal. Red arrows: lesion; green arrow: normal contralateral facial nerve canal. The lesions are consistent with a myeloma deposit.
Normally MS lesions are small ovoid lesions, less than 2 cm. long, oriented perpendicular to the long axis of the brain's ventricles [18] Often they are disposed surrounding a vein [19] Demyelinization by MS. The Klüver-Barrera colored tissue show a clear decoloration in the area of the lesion (Original scale 1:100)