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Advanced glycation end products (AGEs) are proteins or lipids that become glycated as a result of exposure to sugars. [1] They are a bio-marker implicated in aging and the development, or worsening, of many degenerative diseases , such as diabetes , atherosclerosis , chronic kidney disease , and Alzheimer's disease .
Glycation is the non-enzymatic process responsible for many (e.g. micro and macrovascular) complications in diabetes mellitus and is implicated in some diseases and in aging. [2] [3] [4] Glycation end products are believed to play a causative role in the vascular complications of diabetes mellitus. [5]
Fructosamines are compounds that result from glycation reactions between glucose and a primary amine, followed by isomerization via the Amadori rearrangement.Biologically, fructosamines are recognized by fructosamine-3-kinase, which may trigger the degradation of advanced glycation end-products (though the true clinical significance of this pathway is unclear).
Luckily, type 2 diabetes can be managed (and even reversed) with a nutrient-dense diet that focuses on whole foods. Balancing your plate with lean protein, healthy fat, fiber, and complex carbs ...
Eating too much sugar is associated with many of the leading causes of death in the U.S., including heart disease, certain cancers, and type 2 diabetes, among others. ... A high-glycemic diet (one ...
Some studies suggest that even though they’re sugar-free, diet sodas may still come with an increased risk of obesity, type 2 diabetes, stroke, dementia, and heart disease.
Obesity has been found to contribute to approximately 55% of cases of type 2 diabetes; [10] chronic obesity leads to increased insulin resistance that can develop into type 2 diabetes, [11] most likely because adipose tissue (especially that in the abdomen around internal organs) is a source of several chemical signals, hormones and cytokines, to other tissues.
3-Deoxyglucosone (3DG) is a sugar that is notable because it is a marker for diabetes. 3DG reacts with protein to form advanced glycation end-products (AGEs), which contribute to diseases such as the vascular complications of diabetes, atherosclerosis, hypertension, Alzheimer's disease, inflammation, and aging.
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