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The Long–Evans rat is an outbred rat developed by Long and Evans in 1915 by crossbreeding several Wistar females with a wild gray male. Long-Evans rats are white with a black hood, or occasionally white with a brown hood. They are utilized as a multipurpose model organism, frequently in behavioral research, especially in alcohol research ...
Spontaneously hypertensive rat (SHR) is a laboratory rat which is an animal model of primary hypertension, used to study cardiovascular disease. It is the most studied model of hypertension measured as number of publications. [ 1 ]
Lapachol induces genetic damage, specifically clastogenic effects, in rats. [14] Beta-lapachone has a direct cytotoxic effect and the loss of telomerase activity in leukemia cells in vitro. [15] The ethnomedical use of lapacho and other Handroanthus teas is usually short-term, to get rid of acute ailments, and not as a general tonic.
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Rats such as the bandicoot rat (Bandicota bengalensis) are murine rodents related to true rats but are not members of the genus Rattus. [4] [5] Male rats are called bucks; unmated females, does, pregnant or parent females, dams; and infants, kittens or pups. A group of rats is referred to as a mischief. [6]
The active ingredients such as lapachol have been found to possess significant abortifacient and reproductive toxicity effects for rats. [2] [3] [4] Taheebo is the common name for the inner bark of the red or purple lapacho tree. This tree grows high in the Andes of the South American rainforest.
Lapachol is a natural phenolic compound isolated from the bark of the lapacho tree. [3] This tree is known botanically as Handroanthus impetiginosus, but was formerly known by various other botanical names such as Tabebuia avellanedae. [4]
Caspar Wistar (1761–1818), physician and anatomist, grandson of the glassmaker. Isaac J. Wistar (1827-1905), Union general and penologist. Wistar Institute, a biomedical research center in Philadelphia, Pennsylvania, named after the physician. Wistar rat, a strain of albino laboratory rats developed at the institute.