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1α-Hydroxyvitamin D 5 is a chemical derivative of vitamin D 5.The motive to study 1α-hydroxyvitamin D 5 as a potential pharmaceutical drug stemmed from the tendency of calcitriol, a natural metabolite produced in the kidney, to cause toxic hypercalcemia in patients when dosed at concentrations needed to interrupt prostate cancer cells' cycle and stimulate apoptosis.
In vitro studies indicate that vitamin D increases the expression of the tyrosine hydroxylase gene in adrenal medullary cells and affects the synthesis of neurotrophic factors, nitric oxide synthase, and glutathione, which may control the body's response and adaption to stress. [20] VDR expression decreases with age. [1]
Giovannucci is known for his research into the health benefits of obtaining vitamin D through sunlight exposure. [4] [5] He has said that for every death caused by skin cancer resulting from sun exposure, 30 deaths might be prevented due to increased vitamin D intake, [4] and that "It does seem that Vitamin D levels seem to be a real predictor of heart disease."
Vitamin D and Omega-3 Trial (VITAL) [1] was a clinical trial designed to investigate the use of daily dietary supplements of vitamin D and fish oil.. The sponsor of the study was Brigham and Women's Hospital, collaborating with The National Cancer Institute, National Heart, Lung, and Blood Institute, Office of Dietary Supplements, National Institute of Neurological Disorders and Stroke ...
The U.S. Preventive Services Task Force released a draft recommendation advising against using vitamin D to prevent falls and fractures in people over 60. Pharmacist Katy Dubinsky weighs in.
Michael F. Holick (/ ˈ h ɒ l ɪ k / HOLL-ik; [1] born 1946) is an American adult endocrinologist, specializing in vitamin D, such as the identification of both calcidiol, the major circulating form of vitamin D, and calcitriol, the active form of vitamin D. His work has been the basis for diagnostic tests and therapies for vitamin D-related ...
In past studies, researchers have said that low vitamin D levels can contribute to joint pain. Other research has indicated that low vitamin D levels can be a cause of chronic inflammation.
One new BMJ study adds to growing research that excess consumption of omega-6s, ... may interfere with our body’s natural process of fighting cancer cells. ... 5.59 milligrams of vitamin E.
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