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Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), [5] is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1).
osteopontin (OPN) bone sialoprotein (BSP) dentin matrix protein 1 (DMP1) dentin sialophosphoprotein (DSPP) matrix extracellular phosphoglycoprotein (MEPE) The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23. [3]
OPN may stand for: . Osteopontin, a glycoprotein secreted by osteoblasts; Object Process Network, a simulation model meta-language; Optics & Photonics News, a magazine; Oneohtrix Point Never, recording alias of musician Daniel Lopatin
They synthesize dense, crosslinked collagen and specialized proteins in much smaller quantities, including osteocalcin and osteopontin, which compose the organic matrix of bone. In organized groups of disconnected cells, osteoblasts produce hydroxyapatite , the bone mineral , that is deposited in a highly regulated manner, into the inorganic ...
Arginylglycylaspartic acid (RGD) is the most common peptide motif responsible for cell adhesion to the extracellular matrix (ECM), found in species ranging from Drosophila to humans.
Another signaling pathway activated by HA's interaction with CD44 is the Akt pathway which leads to expression of osteopontin, a molecule which can stimulate cell migration. [27] The HA produced by HAS also has been suggested to protect the cancer cell from physical damage while in the circulatory or lymphatic systems.
In addition to low systemic levels of circulating mineral ions (for example, caused by vitamin D deficiency or renal phosphate wasting) that result in decreased bone and tooth mineralization, accumulation of mineralization-inhibiting proteins and peptides (such as osteopontin and ASARM peptides), and small inhibitory molecules (such as ...
Type I collagen composes 90–95% of the organic matrix, with the remainder of the matrix being a homogenous liquid called ground substance consisting of proteoglycans such as hyaluronic acid and chondroitin sulfate, [29] as well as non-collagenous proteins such as osteocalcin, osteopontin or bone sialoprotein. Collagen consists of strands of ...