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Osteopontin also drives metastasis by triggering the release of vascular endothelial growth factor (VEGF) and matrix metalloprotease (MMP), which is inhibited by knocking down osteopontin. This process is also stimulated by nicotine, which is the proposed mechanism by which smokers experience elevated PC risk.
Examples of matricellular proteins include the CCN family of proteins (also known as CCN intercellular signaling protein), [5] fibulins, osteopontin, periostin, SPARC family members, tenascin(s), and thrombospondins. Many of these proteins have important functions in wound healing and tissue repair.
OPN may stand for: . Osteopontin, a glycoprotein secreted by osteoblasts; Object Process Network, a simulation model meta-language; Optics & Photonics News, a magazine; Oneohtrix Point Never, recording alias of musician Daniel Lopatin
Minor, but important, amounts of small proteins, including osteocalcin and osteopontin, are secreted in bone's organic matrix. [21] Osteocalcin is not expressed at significant concentrations except in bone, and thus osteocalcin is a specific marker for bone matrix synthesis. [ 22 ]
104099 Ensembl ENSG00000144668 ENSMUSG00000039115 UniProt Q13797 B8JK39 RefSeq (mRNA) NM_002207 NM_001113514 NM_133721 RefSeq (protein) NP_002198 NP_001106986 NP_598482 Location (UCSC) Chr 3: 37.45 – 37.82 Mb Chr 9: 118.44 – 118.73 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22 ...
osteopontin (OPN) bone sialoprotein (BSP) dentin matrix protein 1 (DMP1) dentin sialophosphoprotein (DSPP) matrix extracellular phosphoglycoprotein (MEPE) The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23. [3]
Osteonectin is a 40 kDa acidic and cysteine-rich glycoprotein consisting of a single polypeptide chain that can be broken into 4 domains: 1) a Ca 2+ binding domain near the glutamic acid-rich region at the amino terminus (domain I), 2) a cysteine-rich domain (II), 3) a hydrophilic region (domain III), and 4) an EF hand motif at the carboxy terminus region (domain IV).
Arginylglycylaspartic acid (RGD) is the most common peptide motif responsible for cell adhesion to the extracellular matrix (ECM), found in species ranging from Drosophila to humans.