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The Golgi apparatus (/ ˈ ɡ ɒ l dʒ i /), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. [1] Part of the endomembrane system in the cytoplasm , it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination.
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. [ 6 ]
They are dyed dark due to their acidity; in the center of the top image, a Golgi Apparatus can be seen, distal from the cell membrane relative to the lysosome . Christian de Duve , at the Laboratory of Physiological Chemistry at the Catholic University of Louvain in Belgium, had been studying the mechanism of action of insulin in liver cells.
The Golgi apparatus (also known as the Golgi body and the Golgi complex) is composed of separate sacs called cisternae. Its shape is similar to a stack of pancakes. The number of these stacks varies with the specific function of the cell. The Golgi apparatus is used by the cell for further protein modification.
27277 Ensembl ENSG00000066455 ENSMUSG00000021192 UniProt Q8TBA6 Q9QYE6 RefSeq (mRNA) NM_005113 NM_001199004 NM_013747 RefSeq (protein) NP_005104 NP_001185933 NP_038775 Location (UCSC) Chr 14: 92.79 – 92.84 Mb Chr 12: 102.44 – 102.46 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Golgin subfamily A member 5 is a protein that in humans is encoded by the GOLGA5 gene. The Golgi ...
The Golgi apparatus plays a pivotal role in N-linked glycosylation, a process that begins in the ER and is elaborated within the Golgi. Through the sequential trimming and addition of sugars like GlcNAc, mannose, galactose, and sialic acid, the Golgi ensures that proteins are properly modified for their final functional roles.
Camillo Golgi (1843–1926), Italian physician and scientist after whom the following terms are named: Golgi apparatus (also called the Golgi body, Golgi complex, or dictyosome), an organelle in a eukaryotic cell; Golgi tendon organ, a proprioceptive sensory receptor organ; Golgi's method or Golgi stain, a nervous tissue staining technique
Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene. [ 5 ] [ 6 ] [ 7 ] Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification.