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  2. Sequence homology - Wikipedia

    en.wikipedia.org/wiki/Sequence_homology

    Top: An ancestral gene duplication produces two paralogs (histone H1.1 and 1.2). A speciation event produces orthologs in the two daughter species (human and chimpanzee). Bottom: in a separate species , a gene has a similar function (histone-like nucleoid-structuring protein) but has a separate evolutionary origin and so is an analog.

  3. Period circadian protein homolog 1 - Wikipedia

    en.wikipedia.org/wiki/Period_circadian_protein...

    18626 Ensembl ENSG00000179094 ENSMUSG00000020893 UniProt O15534 O35973 RefSeq (mRNA) NM_002616 NM_001159367 NM_011065 RefSeq (protein) NP_002607 NP_001152839 NP_035195 Location (UCSC) Chr 17: 8.14 – 8.16 Mb Chr 11: 68.99 – 69 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Period circadian protein homolog 1 is a protein in humans that is encoded by the PER1 gene. Function The ...

  4. Meiotic recombination checkpoint - Wikipedia

    en.wikipedia.org/wiki/Meiotic_recombination...

    In the fruitfly Drosophila, irradiation of germ line cells generates double-strand breaks that result in cell cycle arrest and apoptosis. The Drosophila CHEK2 ortholog mnk and the p53 ortholog dp53 are required for much of the cell death observed in early oogenesis when oocyte selection and meiotic recombination occur. [16]

  5. Homology (biology) - Wikipedia

    en.wikipedia.org/wiki/Homology_(biology)

    The term "ortholog" was coined in 1970 by the molecular evolutionist Walter Fitch. [41] Homologous sequences are paralogous if they were created by a duplication event within the genome. For gene duplication events, if a gene in an organism is duplicated, the two copies are paralogous. They can shape the structure of whole genomes and thus ...

  6. Cyclin-dependent kinase 1 - Wikipedia

    en.wikipedia.org/wiki/Cyclin-dependent_kinase_1

    Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. [5]

  7. Cell cycle checkpoint - Wikipedia

    en.wikipedia.org/wiki/Cell_cycle_checkpoint

    In eukaryotes, the cell cycle consists of four main stages: G 1, during which a cell is metabolically active and continuously grows; S phase, during which DNA replication takes place; G 2, during which cell growth continues and the cell synthesizes various proteins in preparation for division; and the M phase, during which the duplicated ...

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  9. HomoloGene - Wikipedia

    en.wikipedia.org/wiki/HomoloGene

    HomoloGene, a tool of the United States National Center for Biotechnology Information (NCBI), is a system for automated detection of homologs (similarity attributable to descent from a common ancestor) among the annotated genes of several completely sequenced eukaryotic genomes.