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2. CYP3A4 - Wikipedia

   en.wikipedia.org/wiki/CYP3A4

   Cytochrome P450 enzymes metabolize approximately 60% of prescribed drugs, with CYP3A4 responsible for about half of this metabolism; [6] substrates include acetaminophen (paracetamol), codeine, ciclosporin (cyclosporin), diazepam, erythromycin, and chloroquine. [5] The enzyme also metabolizes some steroids and carcinogens. [7]

3. Erythromycin breath test - Wikipedia

   en.wikipedia.org/wiki/Erythromycin_breath_test

   The erythromycin breath test has numerous clinical applications, particularly in transplantation and pharmacology. It is frequently used to evaluate the activity of the CYP3A4 enzyme, which is critical in the metabolism of medications such as cyclosporine and tacrolimus in liver transplant patients.

4. Erythromycin - Wikipedia

   en.wikipedia.org/wiki/Erythromycin

   Most of erythromycin is metabolised by demethylation in the liver by the hepatic enzyme CYP3A4. Its main elimination route is in the bile with little renal excretion, 2%–15% unchanged drug. Erythromycin's elimination half-life ranges between 1.5 and 2.0 hours and is between 5 and 6 hours in patients with end-stage renal disease. Erythromycin ...

5. Macrolide - Wikipedia

   en.wikipedia.org/wiki/Macrolide

   Macrolides, mainly erythromycin and clarithromycin, also have a class effect of QT prolongation, which can lead to torsades de pointes. Macrolides exhibit enterohepatic recycling; that is, the drug is absorbed in the gut and sent to the liver, only to be excreted into the duodenum in bile from the liver. This can lead to a buildup of the ...

6. Hepatotoxicity - Wikipedia

   en.wikipedia.org/wiki/Hepatotoxicity

   A group of enzymes located in the endoplasmic reticulum, known as cytochrome P-450, is the most important family of metabolizing enzymes in the liver. Cytochrome P-450 is not a single enzyme, but rather consists of a closely related family of 50 isoforms; six of them metabolize 90% of drugs.

7. Enterohepatic circulation - Wikipedia

   en.wikipedia.org/wiki/Enterohepatic_circulation

   For example, antibiotics that kill gut bacteria often reduce enterohepatic drug circulation and this requires a temporary increase of the drug's dose until the antibiotic use is discontinued and the gut repopulates with bacteria. This effect of antibiotics on enterohepatic circulation of other drugs is one of several types of drug interactions.

8. Common antibiotic use linked to rise of ‘almost untreatable ...

   www.aol.com/news/common-antibiotic-linked-rise...

   A common antibiotic used to treat liver disease could give rise to an “almost untreatable” superbug, scientists warned in a new study.. The antibiotic, rifaximin, has enabled the global ...

9. Liver function tests - Wikipedia

   en.wikipedia.org/wiki/Liver_function_tests

   Liver function tests (LFTs or LFs), also referred to as a hepatic panel or liver panel, are groups of blood tests that provide information about the state of a patient's liver. [1] These tests include prothrombin time (PT/INR), activated partial thromboplastin time (aPTT), albumin , bilirubin (direct and indirect), and others.