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An excess of vitamin D causes abnormally high blood concentrations of calcium, which can cause overcalcification of the bones, soft tissues, heart and kidneys. In addition, hypertension can result. [2] Symptoms of vitamin D toxicity may include the following: Dehydration; Vomiting; Diarrhea; Decreased appetite; Irritability; Constipation ...
The conversion of 25(OH) vitamin D to 1,25(OH)2 vitamin D is impaired, reducing intestinal calcium absorption and increasing PTH. [2] The kidney fails to respond adequately to PTH, which normally promotes phosphaturia and calcium reabsorption, or to FGF-23, which also enhances phosphate excretion. [2]
Vitamin D deficiency can occur. Vitamin D binding protein is lost. Hypocalcaemia: lack of 25-hydroxycholecalciferol (the way that vitamin D is stored in the body). As vitamin D regulates the amount of calcium present in the blood, a decrease in its concentration will lead to a decrease in blood calcium levels. It may be significant enough to ...
A surplus of vitamin D, though, can be dangerous. ... “More serious symptoms can include stupor, coma, kidney stones, stomach ulcers, nausea, vomiting and diarrhea, and cardiac arrhythmias ...
The kidneys are responsible for converting 25-hydroxyvitamin D to 1,25-hydroxyvitamin D. This is the active form of vitamin D in the body. Kidney disease reduces 1,25-hydroxyvitamin D formation, leading to a deficiency of the effects of vitamin D. [1]
Calcium replacement or vitamin D can ameliorate the symptoms but can increase the risk of kidney stones and chronic kidney disease. [1] Additionally, medications such as recombinant human parathyroid hormone or teriparatide may be given by injection to replace the missing hormone.
An adequate intake of vitamin D may support good immune function and reduce the risk of autoimmune diseases. ... cardiovascular disease, cancer prevention, or death from vitamin D supplementation ...
Vitamin D is a fat-soluble vitamin, meaning that excessive amounts can be damaging so it should be prescribed and monitored by a doctor. Iron- Kidney damage results in inability of the kidney to produce erythropoietin, which stimulates red blood cell production. [5]
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