Search results
Results from the WOW.Com Content Network
Combined use of medications with anticholinergics may cause synergistic (supra-additive), additive, or antagonistic interactions, leading to no therapeutic effect or overdosing. [25] [26] Below listed are some medications or food that can interact with anticholinergics. Medications indicated for: Irregular heartbeat, e.g. disopyramide ...
Physostigmine is one of only a few drugs that can be used as an antidote for anticholinergic poisoning. Nicotine also counteracts anticholinergics by activating nicotinic acetylcholine receptors . Caffeine (although an adenosine receptor antagonist ) can counteract the anticholinergic symptoms by reducing sedation and increasing acetylcholine ...
TCA overdose may occur by accident or purposefully in an attempt to cause death. [2] The toxic dose depends on the specific TCA. [2] Most are non-toxic at less than 5 mg/kg except for desipramine, nortriptyline, and trimipramine, which are generally non-toxic at less than 2.5 mg/kg. [5] [2] In small children one or two pills can be fatal. [6]
Diphenhydramine is a potent antimuscarinic (a competitive antagonist of muscarinic acetylcholine receptors) and, as such, at high doses can cause anticholinergic syndrome. [68] The utility of diphenhydramine as an antiparkinson agent is the result of its blocking properties on the muscarinic acetylcholine receptors in the brain.
Flaccid paralysis resulting from cholinergic crisis can be distinguished from myasthenia gravis by the use of the drug edrophonium (Tensilon), as it only worsens the paralysis caused by cholinergic crisis but strengthens the muscle response in the case of myasthenia gravis. (Edrophonium is a cholinesterase inhibitor, hence increases the ...
Building on past research, a study conducted by the Indiana University School of Medicine suggests anticholinergic drugs of both the over-the-counter and prescription varieties are linked to ...
A toxidrome (a portmanteau of toxic and syndrome, coined in 1970 by Mofenson and Greensher [2]) is a syndrome caused by a dangerous level of toxins in the body. It is often the consequence of a drug overdose. Common symptoms include dizziness, disorientation, nausea, vomiting and oscillopsia.
Although many studies have investigated this link, this was the first study to use a long-term approach (over seven years) to find that dementias associated with anticholinergics may not be reversible even years after drug use stops. [26] Anticholinergic drugs block the action of acetylcholine, which transmits messages in the nervous system. In ...