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Nephrotic syndrome is a collection of symptoms due to kidney damage. This includes protein in the urine , low blood albumin levels , high blood lipids , and significant swelling . Other symptoms may include weight gain, feeling tired, and foamy urine.
A meta-analysis of four randomized controlled trials comparing treatments of membranous nephropathy showed that regimes comprising chlorambucil or cyclophosphamide, either alone or with steroids, were more effective than symptomatic treatment or treatment with steroids alone in inducing remission of the nephrotic syndrome. [citation needed]
Metolazone may be combined with other diuretics (typically loop diuretics) to treat diuretic resistance in congestive heart failure, chronic kidney disease, and nephrotic syndrome. [3] Metolazone and a loop diuretic will synergistically enhance diuresis over the use of either agent alone.
Minimal change disease (MCD), also known as lipoid nephrosis or nil disease, among others, is a disease affecting the kidneys which causes nephrotic syndrome. [1] Nephrotic syndrome leads to the loss of significant amounts of protein to the urine (proteinuria), which causes the widespread edema (soft tissue swelling) and impaired kidney function commonly experienced by those affected by the ...
Glomerulonephrosis is a non-inflammatory disease of the kidney presenting primarily in the glomerulus (a glomerulopathy) as nephrotic syndrome. The nephron is the functional unit of the kidney and it contains the glomerulus, which acts as a filter for blood to retain proteins and blood lipids.
Treatment Corticosteroids Rapidly progressive glomerulonephritis ( RPGN ) is a syndrome of the kidney that is characterized by a rapid loss of kidney function, [ 4 ] [ 5 ] (usually a 50% decline in the glomerular filtration rate (GFR) within 3 months) [ 5 ] with glomerular crescent formation seen in at least 50% [ 5 ] or 75% [ 4 ] of glomeruli ...
Three classes of diabetes medications – GLP-1 agonists, DPP-4 inhibitors, and SGLT2 inhibitors– are also thought to slow the progression of diabetic nephropathy. [ 12 ] Diabetic nephropathy is the most common cause of end-stage renal disease and is a serious complication that affects approximately one quarter of adults with diabetes in the ...
Edema - Volume overload associated with liver cirrhosis, heart failure, or nephrotic syndrome [11] Cerebral edema - intravenous furosemide can be combined with mannitol to initiate rapid diuresis. However, the optimum duration of such treatment remains unknown.
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