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It is also supported by subchronic rodent toxicity experiments, which demonstrate a set of gross and microscopic findings similar to those known to be caused by Zn 2+ deficiency. [16] Under the transmetallation hypothesis, we can expect that subtle changes in formulation can affect the intrinsic safety of gadolinium complexes, which is indeed ...
HOPO 14-1 is an investigational drug product for removing radioactive contaminants from the body. It is an oral capsule designed to act as a defence against radioactive threats such as nuclear power plant accidents or dirty bomb attacks.
Gadolinium is a silvery-white metal when oxidation is removed. It is a malleable and ductile rare-earth element. Gadolinium reacts with atmospheric oxygen or moisture slowly to form a black coating. Gadolinium below its Curie point of 20 °C (68 °F) is ferromagnetic, with an attraction to a magnetic field higher than that of nickel.
As a free solubilized aqueous ion, gadolinium(III) is highly toxic, but the chelated compounds are generally regarded as safe for individuals without kidney disease. Free Gd 3+ has a median lethal dose of 0.34 mmol/kg (IV, mouse) [ 27 ] or 100–200 mg/kg, but the LD50 is increased by a factor of 31 times [ 28 ] when Gd 3+ is chelated.
Gadodiamide is one of the main GBCA associated with nephrogenic systemic fibrosis (NSF), a toxic reaction occurring in some people with kidney problems. [6] No cases have been seen in people with normal kidney function. [7] A 2015 study found gadolinium deposited in the brain tissue of people who had received gadodiamide. [8]
A hallmark of modern HIV treatment is viral suppression, or reducing the presence of HIV in one's blood to very low levels, which keeps patients healthy and prevents transmission. Nearly 2 in 3 ...
One of the leading theories behind Alzheimer’s disease is that the toxic accumulation of the proteins beta-amyloid and tau in the brain can cause many of the symptoms related to this condition.
Sodium thiosulfate has been observed to help in the treatment of a rare systemic fibrosis condition caused by gadolinium-based contrast media in patients with kidney failure. [ 19 ] The compound can also be used to measure the volume of extracellular body fluid and the renal glomerular filtration rate .