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Legionella is a genus of gram-negative bacteria that can be seen using a silver stain or grown in a special media that contains cysteine, an amino acid.It is known to cause legionellosis [3] (all illnesses caused by Legionella) including a pneumonia-type illness called Legionnaires' disease and a mild flu-like illness called Pontiac fever. [3]
Legionella pneumophila, the primary causative agent for Legionnaire's disease, is an aerobic, pleomorphic, flagellated, non-spore-forming, Gram-negative bacterium. [ 1 ] [ 2 ] L. pneumophila is a intracellular parasite that preferentially infects soil amoebae and freshwater protozoa for replication.
The number of cases that occur globally is not known. [1] Legionnaires' disease is the cause of an estimated 2–9% of pneumonia cases that are acquired outside of a hospital. [1] An estimated 8,000 to 18,000 cases a year in the United States require hospitalization. [9] Outbreaks of disease account for a minority of cases.
Legionella pneumophila is the most common cause, but sometimes other species of Legionella bacteria also cause Legionnaires' disease. [ 15 ] [ 16 ] The terms "Philadelphia fever" and "Legion fever" appear to have been used at the time of the outbreak and for shortly thereafter, [ 17 ] although at least one 2008 source which covers disease in a ...
To avoid competition with host cells for glucose which is the main energy source used by human cells, many pathogens including the respiratory pathogen Haemophilus influenzae specialise in using other carbon sources such as lactate that are abundant in the human body [26]
Caused by bacteria belonging to genus Legionella (90% of cases caused by Legionella pneumophila) Legionella is a very common organism that reproduces to high numbers in warm water; [18] but only causes severe disease when aerosolized. [19] Pontiac fever produces milder symptoms resembling acute influenza without pneumonia.
Neutrophils extravasate from blood vessels to the site of tissue injury or infection during the innate immune response.. In immunology, leukocyte extravasation (also commonly known as leukocyte adhesion cascade or diapedesis – the passage of cells through the intact vessel wall) is the movement of leukocytes (white blood cells) out of the circulatory system (extravasation) and towards the ...
Infection after surgery is relatively uncommon, but occurs as much as 33% in specific types of surgeries. Infections of surgical sites range from 1% to 33%. MRSA sepsis that occurs within 30 days following a surgical infection has a 15–38% mortality rate; MRSA sepsis that occurs within one year has a mortality rate of around 55%.