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Phage therapy is the use of bacteriophages to treat bacterial infections. Bacteriophage treatment offers a possible alternative to conventional antibiotic treatments for bacterial infection. [55] It is conceivable that, although bacteria can develop resistance to phages, the resistance might be easier to overcome than resistance to antibiotics.
Phage therapy also allows for the possibility of biofilm penetration in cases where antibiotics are ineffective due to the increased resistance of biofilm-forming pathogens. [9] One major drawback to phage therapy is the evolution of phage-resistant microbes which was seen in a majority of phage therapy experiments aimed to treat sepsis and ...
Phage therapy relies on the use of naturally occurring bacteriophages to infect and lyse bacteria at the site of infection in a host. Due to current advances in genetics and biotechnology these bacteriophages can possibly be manufactured to treat specific infections. [ 271 ]
As it was more reliable and easier to use than phage therapy, it soon became the method of choice, despite side effects and problems with resistant bacteria. Phage therapy remained a common treatment in the states of the Soviet Union , though, until its deconstruction.
Phage therapy has gained recent attention in the United States as an alternative to standard antibiotic therapy. [ 5 ] [ 6 ] [ 7 ] It has been in practice for just over 100 years in countries such as Russia and Georgia , but due to the recent clinical attention of antibiotic resistance , Western countries have slowly been integrating phage ...
Phage therapy is a technique that was discovered before antibiotics, but fell to the wayside as antibiotics became predominate. It is now being considered as a potential solution to increasing antimicrobial resistance. Bacteriophages, viruses that only infect bacteria, can specifically target the bacteria of interest and inject their genome ...
Phage therapy—viruses that specifically target pathogenic bacteria—has been developed over the last 80 years, primarily in the former Soviet Union, where it was used to prevent diarrhea caused by E. coli. [55] Presently, phage therapy for humans is available only at the Phage Therapy Center in the Republic of Georgia and in Poland. [56]
Every 12 hours, the patient received a treatment of the bacteriophage cocktail. [14] One day of treatment showed high bacteriophage levels in the bloodstream. [14] This suggested that they were being released into the bloodstream and replicating to infect bacteria. [14] No significant side effects were reported. [14]