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  2. Hepatocyte growth factor receptor - Wikipedia

    en.wikipedia.org/wiki/Hepatocyte_growth_factor...

    Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. [7] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.

  3. Mesenchymal–epithelial transition - Wikipedia

    en.wikipedia.org/wiki/Mesenchymal–epithelial...

    MET is an essential process in embryogenesis to gather mesenchymal-like cells into cohesive structures. [1] Although the mechanism of MET during various organs morphogenesis is quite similar, each process has a unique signaling pathway to induce changes in gene expression profiles.

  4. Receptor tyrosine kinase - Wikipedia

    en.wikipedia.org/wiki/Receptor_tyrosine_kinase

    These adaptor proteins link RTK activation to downstream signal transduction pathways, such as the MAP kinase signalling cascade. [2] An example of a vital signal transduction pathway involves the tyrosine kinase receptor, c-met, which is required for the survival and proliferation of migrating myoblasts during myogenesis. A lack of c-met ...

  5. Methyltransferase - Wikipedia

    en.wikipedia.org/wiki/Methyltransferase

    Overall, it responds to mutations in DNA, signaling to the cell to fix them or to initiate cell death so that these mutations cannot contribute to cancer. NF-κB (a protein involved in inflammation) is a known methylation target of the methyltransferase SETD6, which turns off NF-κB signaling by inhibiting of one of its subunits, RelA.

  6. Enkephalin - Wikipedia

    en.wikipedia.org/wiki/Enkephalin

    The met-enkephalin peptide sequence is coded for by the enkephalin gene; the leu-enkephalin peptide sequence is coded for by both the enkephalin gene and the dynorphin gene. [3] The proopiomelanocortin gene ( POMC ) also contains the met-enkephalin sequence on the N-terminus of beta-endorphin, but the endorphin peptide is not processed into ...

  7. Macc1, met transcriptional regulator - Wikipedia

    en.wikipedia.org/wiki/Macc1,_met_transcriptional...

    346389 238455 Ensembl ENSG00000183742 ENSMUSG00000041886 UniProt Q6ZN28 E9PXX8 RefSeq (mRNA) NM_182762 NM_001163136 RefSeq (protein) NP_877439 NP_001156608 Location (UCSC) Chr 7: 20.13 – 20.22 Mb Chr 12: 119.28 – 119.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse MACC1, MET transcriptional regulator is a protein that in humans is encoded by the MACC1 gene. Function MACC1 is a ...

  8. Epithelial–mesenchymal transition - Wikipedia

    en.wikipedia.org/wiki/Epithelial–mesenchymal...

    Epithelial and mesenchymal cells differ in phenotype as well as function, though both share inherent plasticity. [2] Epithelial cells are closely connected to each other by tight junctions , gap junctions and adherens junctions , have an apico-basal polarity , polarization of the actin cytoskeleton and are bound by a basal lamina at their basal ...

  9. Biomarkers of diabetes - Wikipedia

    en.wikipedia.org/wiki/Biomarkers_of_diabetes

    There is a study that indicate that HGF/c-Met signalling is essential for maternal β-cell adaptation during pregnancy and that its absence/attenuation leads to gestational diabetes mellitus. [10] [9] Betatrophin: is a novel protein predominantly expressed in human liver and adipose tissues.