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A review of the results of nine randomized control trials which compared oral doses of both, found that calcifediol was 3.2-fold more potent than cholecalciferol. [6] Calcifediol is better absorbed from the intestine and has greater affinity for the vitamin-D-binding protein, both of which increase its bioavailability. [ 20 ]
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
The main difference here is that vitamin D2 is found in plant-based products such as mushrooms, fortified foods, and supplements, whereas vitamin D3 is found in animal-based foods such as butter ...
[75] [76] A review did not find any effect from supplementation on the rates of non-skeletal disease, other than a tentative decrease in mortality in the elderly. [77] Vitamin D supplements do not alter the outcomes for myocardial infarction, stroke or cerebrovascular disease, cancer, bone fractures or knee osteoarthritis. [10] [78]
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Supplements are not recommended for prevention of cancer as any effects of cholecalciferol are very small. [35] Although correlations exist between low levels of blood serum cholecalciferol and higher rates of various cancers, multiple sclerosis , tuberculosis , heart disease, and diabetes, [ 36 ] the consensus is that supplementing levels is ...
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