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Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative.It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects.
NyQuil was first marketed in the United States in 1966. [2] [3] Products. NyQuil Cold/Flu Multisymptom Relief ... Diphenhydramine HCl 50 mg (antihistamine)
Diphenhydramine is a first-generation antihistamine and an anticholinergic drug. Anticholinergic drugs block the action of acetylcholine , a neurotransmitter in the central nervous system . [ 13 ] Studies propose that long-term use of anticholinergic drugs is associated with an increased risk for dementia among older people.
Dimenhydrinate is an over-the-counter (OTC) first-generation antihistamine indicated for the prevention and relief of nausea and vomiting from a number of causes, including motion-sickness and post-operative nausea. [2] Dimenhydrinate can also be used for Insomnia, but this is an off label use. [5]
In July 1975, the J. B. Williams Co. began marketing Sominex 2. [37] On November 24, 1975, Attorney General Evelle J. Younger filed suit on behalf of the State of California against Williams Co., stating that the product did not warn against use by pregnant or nursing women or persons with asthma or COPD, nor did it notify consumers that it should not be used in conjunction with alcohol. [38]
In 1943, one of his students, Fred Huber, synthesized diphenhydramine. Rieveschl worked with Parke-Davis to test the compound, and the company licensed the patent from him. In 1947 Parke-Davis hired him as their director of research. While he was there, he led the development of a similar drug, orphenadrine. [5]
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The first-generation sedating antihistamines diphenhydramine, doxepin, doxylamine, and pyrilamine are the most widely used medications in the world for preventing and treating insomnia. [6] As of 2004, doxylamine and diphenhydramine, which are both over-the-counter medications, were the agents most commonly used to treat short-term insomnia. [11]