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Schematic representation of transmembrane proteins: 1) a single-pass membrane protein 2) a multipass membrane protein (α-helix) 3) a multipass membrane protein β-sheet. The membrane is represented in light yellow. A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane.
The database provides information about the individual proteins including computationally generated three-dimensional models of their transmembrane alpha-helices spatially arranged in the membrane, topology, intracellular localizations, amino acid sequences, domain architecture, functional annotation and available experimental structures from ...
The Transporter Classification Database (or TCDB) is an International Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system for membrane transport proteins, including ion channels.
13409 Ensembl ENSG00000165091 ENSMUSG00000024749 UniProt Q8TDI8 Q8R4P5 RefSeq (mRNA) NM_138691 NM_028953 RefSeq (protein) NP_619636 NP_083229 Location (UCSC) Chr 9: 72.52 – 72.84 Mb Chr 19: 20.76 – 20.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene. TMC1 contains six transmembrane ...
Although several protein families have four transmembrane alpha-helices, tetraspanins are defined by conserved amino acid sequences including four or more cysteine residues in the EC2 domain, with two in a highly conserved 'CCG' motif. Tetraspanins are often thought to act as scaffolding proteins, anchoring multiple proteins to one area of the ...
Transmembrane protein 145 isoform 1 is rich in phenylalanine and tyrosine. [23] The subcellular localization of the human TMEM145 protein is the plasma membrane and cytoskeleton . [ 8 ] This protein has a signal peptide from amino acid 1-29 and a cleavage site between amino acid 29 and 30. [ 24 ]
329909 Ensembl ENSG00000143001 ENSMUSG00000085933 UniProt Q8N0U2 n/a RefSeq (mRNA) NM_182532 NM_001370848 RefSeq (protein) NP_872338 n/a Location (UCSC) Chr 1: 54.98 – 54.99 Mb Chr 4: 106.36 – 106.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transmembrane protein 61 (TMEM61) is a protein that is encoded by the TMEM61 gene in humans. It is located on the first chromosome in ...
TMEM19 is a protein spanning 336 amino acids. It has 6 transmembrane regions. The protein is found at moderate levels in the body, with the highest expression found in superior cervical ganglia and cardiac myocytes. [10] TMEM19 interacts with many proteins, most of these proteins are localized around membranes found in the cell.