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[2] [1] The cure rates against BV with TOL-463 were said to be comparable to those with recently approved antibiotic treatments like single-dose oral secnidazole (58%) and single-dose metronidazole vaginal gel (41%). [1] As of July 2022, TOL-463 is in phase 2 clinical trials for the treatment of BV and VVC. [3]
However, due to high recurrence rates, alternative treatment options for BV are still in development. Topical boric acid has been shown to be effective against BV, due to its ability to remove BV-specific biofilms and enhance eradication of G. vaginalis and other potential bacterial pathogens, resulting in reduced recurrence of symptomatic BV. [16]
BV is a risk factor for viral shedding and herpes simplex virus type 2 infection. BV may increase the risk of infection with or reactivation of human papillomavirus (HPV). [22] [24] In addition, bacterial vaginosis as either pre-existing, or acquired, may increase the risk of pregnancy complications, most notably premature birth or miscarriage.
Structurally it actually methyl-metronidazole. Effectiveness in the treatment of dientamoebiasis has been reported. [1] It has also been tested against Atopobium vaginae. [2] In the United States, secnidazole is FDA approved for the treatment of bacterial vaginosis and trichomoniasis in adult women. [3]
Bacterial vaginosis According to Jerome Chelliah, M.D., board-certified OBGYN at HerMD , bacterial vaginosis (BV) is the most common type of vaginitis (or inflammation of the vagina) and something ...
Bacterial vaginosis is caused by an imbalance of the naturally occurring bacteria in the vagina. [ 1 ] [ 2 ] The normally predominant species of Lactobacilli are markedly reduced. [ 3 ] This is the list of organisms that are found in the vagina that are associated with bacterial vaginosis , an infectious disease of the vagina caused by ...
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