Search results
Results from the WOW.Com Content Network
Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...
Orexin, otherwise known as hypocretin, is a neuropeptide that acts within the brain to regulate appetite and wakefulness as well as a number of other cognitive and physiological processes. [27] [38] [39] Loss of these orexin-producing neurons causes narcolepsy and most individuals with narcolepsy have a reduced number of these neurons in their ...
Once made, the orexin peptides can bind to the orexin receptor; which is a G protein-coupled receptor. This receptor senses molecules outside the cell and activates inside signal transduction pathways to elicit cellular responses. Research shows that an absence of orexin-A appears to cause narcolepsy. Deficit amounts of orexin-A will make ...
Cataplexy is the first symptom to appear in about 10% of cases of narcolepsy, [2] caused by an autoimmune destruction of hypothalamic neurons that produce the neuropeptide hypocretin (also called orexin), which regulates arousal and has a role in stabilization of the transition between wake and sleep states. [3]
The endogenous orexin neuropeptides, orexin A and orexin B, are involved in the regulation of sleep–wake cycles and act to promote wakefulness. [33] [16] [7] Deficiency of orexin signaling is thought to be the primary cause of the sleep disorder narcolepsy. [33] [16] Disturbances in orexin signaling may also be involved in insomnia. [33]
A century ago, iodine deficiency affected kids across large swaths of the country. Although most people are still getting enough, researchers have increasingly been reporting low levels of iodine ...
Orexin deficiency has been identified as responsible for narcolepsy. [10] Research suggests that orexin and histamine neurons play distinct, but complementary roles in controlling wakefulness with orexin being more involved with wakeful behavior and histamine with cognition and activation of cortical EEG. [11]
The Times story also cited a buprenorphine study by researchers in Sweden that looked at “100 autopsies where buprenorphine had been detected.” According to the Times, the study found that “in two-thirds, it was the direct cause of death, mostly in combination with other drugs.” It was a misreading of the study.