Search results
Results from the WOW.Com Content Network
Alexander A. Borbély (born 1939 in Budapest) is a Hungarian-Swiss pharmacologist known for his sleep research.. Borbély proposed the two-process model of sleep regulation in 1982 which postulates there are two complementary processes (S and C, which stands for Sleep and Circadian, respectively) which together account for one's sleep schedule. [1]
In 1993, a different model called the opponent process model [98] was proposed. This model explained that these two processes opposed each other to produce sleep, as against Borbely's model. According to this model, the SCN, which is involved in the circadian rhythm, enhances wakefulness and opposes the homeostatic rhythm.
Serge Daan, together with Borbély and Beersma, developed a model which convincingly explained the observations. It was called the two-process model of sleep regulation and explained human sleep regulation in terms of two key processes: a circadian pacemaker, and a homeostatic drive to sleep that increases during wake and decreases during sleep ...
In the two process model of sleep, it has been proposed, that depression is characterized by a deficiency in the building up of process S. [27] Therefore, sleep deprivation might increase process S in the beginning, but a relapse occurs, when sleep deprivations isn't applied anymore and process S returns to a low level. [27]
Main page; Contents; Current events; Random article; About Wikipedia; Contact us
This model proposes a homeostatic process (Process S) and a circadian process (Process C) that interact to define the time and intensity of sleep. [71] Process S represents the drive for sleep, increasing during wakefulness and decreasing during sleep until a defined threshold level, while Process C is the oscillator responsible for these levels.
1987: Demonstrated that sleep timing can be shifted by bright light [9] 1988: Identified gender differences in human sleep [11] 1994/5: Characterized the circadian process regulating human sleep [12] 1999: Discovered how circadian regulation of sleep changes with ageing [13] 2004: Discovered melatonin's effects on human sleep timing [9]
The dysregulation model is supported by neuroanatomical, physiological, and subjective self-report studies. Emotional brain regions (e.g. the amygdala) have shown 60% greater reactivity to emotionally negative photographs following one night of sleep deprivation, as measured by functional magnetic resonance imaging. [5]