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H3K4me3 is an epigenetic modification to the DNA packaging protein Histone H3 that indicates tri-methylation at the 4th lysine residue of the histone H3 protein and is often involved in the regulation of gene expression. [1] The name denotes the addition of three methyl groups (trimethylation) to the lysine 4 on the histone H3 protein.
Microbes are ideally suited for biochemical and genetics studies and have made huge contributions to these fields of science such as the demonstration that DNA is the genetic material, [49] [50] that the gene has a simple linear structure, [51] that the genetic code is a triplet code, [52] and that gene expression is regulated by specific ...
Research on long-term memory storage in humans indicates that memory is maintained by DNA methylation, [34] Rats in which a new, strong long-term memory is induced due to contextual fear conditioning have reduced expression of about 1,000 genes and increased expression of about 500 genes in the hippocampus region of the brain. These changes ...
Enhancers control cell-type-specific gene expression programs, most often by looping through long distances to come in physical proximity with the promoters of their target genes. [39] In a study of brain cortical neurons, 24,937 loops were found, bringing enhancers to promoters. [ 36 ]
The process of gene expression is used by all known life—eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses—to generate the macromolecular machinery for life. In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, i.e. observable ...
Multiple studies have suggested that increased SINE activity is correlated with certain gene-expression profiles and post-transcription regulation of certain genes. [ 41 ] [ 42 ] [ 43 ] In fact, Peterson et al. 2013 demonstrated that high SINE RNA expression correlates with post-transcriptional downregulation of BRCA1 , a tumor suppressor ...
The origin of the term "housekeeping gene" remains obscure. Literature from 1976 used the term to describe specifically tRNA and rRNA. [6] For experimental purposes, the expression of one or multiple housekeeping genes is used as a reference point for the analysis of expression levels of other genes.
However, recent studies are now starting to appreciate the importance of non-poly(A) RNA, such as long-noncoding RNA and microRNAs in gene expression regulation. Small-seq is a single-cell method that captures small RNAs (<300 nucleotides) such as microRNAs, fragments of tRNAs and small nucleolar RNAs in mammalian cells. [ 68 ]