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A reverse transcriptase (RT) is an enzyme used to convert RNA genome to DNA, a process termed reverse transcription.Reverse transcriptases are used by viruses such as HIV and hepatitis B to replicate their genomes, by retrotransposon mobile genetic elements to proliferate within the host genome, and by eukaryotic cells to extend the telomeres at the ends of their linear chromosomes.
Later that year, Temin showed that certain tumor viruses carried the enzymatic ability to reverse the flow of information from RNA back to DNA using reverse transcriptase. Reverse transcriptase was also independently and simultaneously discovered in association with the murine leukemia virus by David Baltimore at the Massachusetts Institute of ...
[16] [20] He went on to discover reverse transcriptase (RTase or RT) – the enzyme that polymerizes DNA from an RNA template. In doing so, he discovered a distinct class of viruses, later called retroviruses, that use an RNA template to catalyze synthesis of viral DNA. [21]
Cech discovered that RNA could itself cut strands of RNA, suggesting that life might have started as RNA. [1] ... TERT (telomerase reverse transcriptase), ...
Reverse transcriptase (RT) is an enzyme that controls the replication of the genetic material of HIV and other retroviruses. [1] The enzyme has two enzymatic functions. Firstly it acts as a polymerase where it transcribes the single-stranded RNA genome into single-stranded DNA and subsequently builds a complementary strand o
The reverse transcriptase of HIV-1 has been the main foundation for the development of anti-HIV drugs. [5] The first nucleoside reverse-transcriptase inhibitor with in vitro anti-HIV activity was zidovudine. [6] Since zidovudine was approved in 1987, six nucleosides and one nucleotide reverse-transcriptase inhibitor (NRTI) have been approved by ...
1970: Howard Temin and David Baltimore independently discovered reverse transcriptase enzymes. The Knuth–Morris–Pratt string searching algorithm was developed by Donald Knuth and Vaughan Pratt and independently by J. H. Morris.
In 1971, Beljanski discovered reverse transcriptase in bacteria. [4] [5] This was part of a larger research on DNA and RNA that led him to oppose the central dogma of molecular biology promoted by Jacques Monod, head of the Pasteur Institute.
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