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Streptococcus pneumoniae can be differentiated from the viridans streptococci, some of which are also alpha-hemolytic, using an optochin test, as S. pneumoniae is optochin-sensitive. S. pneumoniae can also be distinguished based on its sensitivity to lysis by bile, the so-called "bile solubility test".
Optochin (or ethylhydrocupreine hydrochloride) is a derivative of quinine introduced in 1911 by Morgenroth and Levy with the intention to treat pneumococci infection. [1] In very high dilutions, it inhibits the growth of representatives of all four groups of pneumococci in vitro .
Pneumococcal infection is an infection caused by the bacterium Streptococcus pneumoniae. [1]S. pneumoniae is a common member of the bacterial flora colonizing the nose and throat of 5–10% of healthy adults and 20–40% of healthy children. [2]
Viridans streptococci can be differentiated from Streptococcus pneumoniae using an optochin test, as viridans streptococci are optochin-resistant; they also lack either the polysaccharide-based capsule typical of S. pneumoniae or the Lancefield antigens of the pyogenic members of the genus. [5]
Streptococcus pseudopneumoniae is a gram-positive coccus that may cause pneumonia in humans. [1] [2] It was first described in 2004. [1] The organism is often mistaken for S. pneumoniae [1] and its clinical importance is as yet uncertain. It seems likely that most cases of S. pseudopneumoniae pneumonia are misdiagnosed as S. pneumoniae. [2]
Streptococcus pneumoniae is the most common bacterial cause of pneumonia in all age groups except newborn infants. Streptococcus pneumoniae is a Gram-positive bacterium that often lives in the throat of people who do not have pneumonia. Other important Gram-positive causes of pneumonia are Staphylococcus aureus and Bacillus anthracis.
With the increase in drug-resistant Streptococcus pneumoniae, antibiotics such as cefpodoxime may become more popular. [21] Hospitalized children receive intravenous ampicillin, ceftriaxone or cefotaxime, and a recent study found that a three-day course of antibiotics seems sufficient for most mild-to-moderate CAP in children. [22]
The infections are typically characterized by either meningitis or sepsis, and are caused by encapsulated organisms including Streptococcus pneumoniae. [3] It is a medical emergency and requires immediate treatment. Death has been reported to occur within 12 hours. [4]
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