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Bone marrow failure in both children and adults can be either inherited or acquired. Inherited bone marrow failure is often the cause in young children, while older children and adults may acquire the disease later in life. [3] Acquired bone marrow failure may be due to aplastic anemia [4] or myelodysplastic syndrome.
Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity , carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes). [1]
Primary bone marrow edema is also referred to as spontaneous bone marrow edema, or bone marrow edema syndrome (BMES). This category of BME does not have a particular cause but is self-limiting in nature, meaning that symptoms usually resolve by themselves within three to nine months after onset without pathological consequences.
Myelophthisic anemia (or myelophthisis) is a severe type of anemia found in some people with diseases that affect the bone marrow. Myelophthisis refers to the displacement of hemopoietic bone-marrow tissue [1] by fibrosis, tumors, or granulomas. The word comes from the roots myelo-, which refers to bone marrow, and phthisis, shrinkage or atrophy.
When a person has primary bone cancer, the cancer cells are bone cells that have become cancerous. According to the NHS , around 550 cases of primary bone cancer are diagnosed each year in the UK.
Indicators of a poor prognosis: Advanced age; severe neutropenia or thrombocytopenia; high blast count in the bone marrow (20–29%) or blasts in the blood; Auer rods; absence of ringed sideroblasts; abnormal localization or immature granulocyte precursors in bone marrow section; completely or mostly abnormal karyotypes, or complex marrow ...
More mysterious symptoms started showing up—and I finally hit my breaking point. After about three months, I got a rash all over my legs. ... which could be a sign of infection or a bone marrow ...
Patients typically present in early childhood with cerebellar hypoplasia, immunodeficiency, progressive bone marrow failure, and intrauterine growth restriction. [2] The primary cause of death in Hoyeraal–Hreidasson syndrome is bone marrow failure, but mortality from cancer and pulmonary fibrosis is also significant. [4] [5] [6]