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Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H ...
In asymmetric trifluoromethylation the trifluoromethyl group is added to the substrate in an enantioselective way. [74] [75] Ruppert's reagent has been used for this purpose in an asymmetric induction approach to functionalise chiral amino acid derivates, [76] saccharides, [77] and steroids.
Two other isomers are also known: 2-trifluoromethylbenzaldehyde and 3-trifluoromethylbenzaldehyde. These compounds are derivatives of benzaldehyde with trifluoromethyl substituents. The CF 3 group enhances the electrophilicity of the formyl group and provides a label for analysis by fluorine-19 nuclear magnetic resonance spectroscopy.
Trifluoromethyltrimethylsilane (known as Ruppert-Prakash reagent, TMSCF 3) is an organosilicon compound with the formula CF 3 Si(CH 3) 3.It is a colorless liquid. The compound is a reagent used in organic chemistry for the introduction of the trifluoromethyl group.
Many organofluorine compounds are generated from reagents that deliver perfluoroalkyl and perfluoroaryl groups. (Trifluoromethyl)trimethylsilane, CF 3 Si(CH 3) 3, is used as a source of the trifluoromethyl group, for example. [24] Among the available fluorinated building blocks are CF 3 X (X = Br, I), C 6 F 5 Br, and C 3 F 7 I.
The story of pantoprazole's discovery is a good example of the stepwise development of PPIs. The main focus of modification of timoprazole was the benzimidazole part of its structure. Addition of a trifluoromethyl group to the benzimidazole moiety led to a series of very active
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Trifluoromethoxy group. The trifluoromethoxy group is the chemical group –O– CF 3.It can be seen as a methoxy group –O– CH 3 whose hydrogen atoms are replaced by fluorine atoms; or as a trifluoromethyl group attached to the rest of the molecule by a bridging oxygen atom; either leads to viable syntheses. [1]