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Nicotinamide adenine dinucleotide phosphate, abbreviated NADP [1] [2] or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source'). NADPH is the reduced form, whereas NADP + is the ...
A biological coenzyme that acts as an electron carrier in enzymatic reactions. NADP is a reducing agent in anabolic reactions like the Calvin cycle and lipid and nucleic acid syntheses. NADP exists in two forms: NADP+, the oxidized form, and NADPH, the reduced form.
NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) is a membrane-bound enzyme complex that faces the extracellular space. It can be found in the plasma membrane as well as in the membranes of phagosomes used by neutrophil white blood cells to engulf microorganisms.
In fatty synthesis, the reducing agent is NADPH, whereas NAD is the oxidizing agent in beta-oxidation (the breakdown of fatty acids to acetyl-CoA). This difference exemplifies a general principle that NADPH is consumed during biosynthetic reactions, whereas NADH is generated in energy-yielding reactions. [7]
This category groups enzymes that use nicotinamide adenine dinucleotide (NADP + and its reduced form, NADPH) in redox reactions. See also Category:NADH-dependent enzymes.. In general, the NADP is not stably associated with the enzyme, being a coenzyme; hence, we call such enzymes "NADPH-dependent" enzymes, rather than simply "NADPH enzymes".
The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage from compounds like hydrogen peroxide. [1] Of greater quantitative importance is the production of NADPH for tissues involved in biosynthesis of fatty acids or isoprenoids , such as the liver, mammary glands ...
In enzymology, a NADPH—hemoprotein reductase is an enzyme that catalyzes the chemical reaction. NADPH + H + + n oxidized hemoprotein NADP + + n reduced hemoprotein. The three substrates of this enzyme are NADPH, H +, and oxidized hemoprotein, whereas its two products are NADP + and reduced hemoprotein.
Respiratory burst requires a 10 to 20 fold increase in oxygen consumption through NADPH oxidase (NOX2 in humans) activity. NADPH is the key substrate of NOX2, and bears reducing power. Glycogen breakdown is vital to produce NADPH. This occurs via the pentose phosphate pathway.