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Stereocilia (or stereovilli or villi) are non-motile apical cell modifications. They are distinct from cilia and microvilli , but are closely related to microvilli. They form single "finger-like" projections that may be branched, with normal cell membrane characteristics.
Resembling hair-like projections, the stereocilia are arranged in bundles of 30–300. [3] Within the bundles the stereocilia are often lined up in several rows of increasing height, similar to a staircase. At the core of these hair-like stereocilia are rigid cross-linked actin filaments, which can renew every
161497 140476 Ensembl ENSG00000242866 ENSMUSG00000033498 UniProt Q7RTU9 Q8VIM6 RefSeq (mRNA) NM_153700 NM_080459 RefSeq (protein) NP_714544 NP_536707 Location (UCSC) Chr 15: 43.6 – 43.62 Mb Chr 2: 121.19 – 121.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Stereocilin is a protein that in humans is encoded by the STRC gene. The STRC gene provides instructions for creating a ...
These microscopic structures possess stereocilia and one kinocilium which are located within the gelatinous otolithic membrane. The membrane is further weighted with otoliths. Movement of the stereocilia and kinocilium enable the hair cells of the saccula and utricle to detect motion.
The stereocilia atop the IHCs move with this fluid displacement and in response their cation, or positive ion selective, channels are pulled open by cadherin structures called tip links that connect adjacent stereocilia. [9] The organ of Corti, surrounded in potassium-rich fluid endolymph, lies on the basilar membrane at the base of the scala ...
The hair cells are mechanoreceptors which have 40 to 70 stereocilia and only one true cilium called a kinocilium. The kinocilium is the only sensory aspect of the hair cell and is what causes hair cell polarization.
The macula of saccule lies in a nearly vertical position. It is a 2mm by 3mm patch of hair cells. Each hair cell of the macula contains 40 to 70 stereocilia and one true cilia, called a kinocilium. A gelatinous cover called the otolithic membrane envelops the tips of the stereocilia and kinocilium.
The stereocilia are oriented by the striola, a curved ridge that runs through the middle of the macula; in the saccule they are oriented away from the striola [2] The tips of the stereocilia and kinocilium are embedded in a gelatinous otolithic membrane. This membrane is weighted with protein-calcium carbonate granules called otoliths, which ...