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Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions. The first typical ...
Thioridazine (Mellaril or Melleril) is a first generation antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. The branded product was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias. However, generic versions are still available in ...
Toggle Antipsychotics subsection. 1.1 Antipsychotic esters. 1.1.1 Typical antipsychotics. 1.1.2 Atypical antipsychotics. 2 See also. 3 References. 4 External links.
A 2015 meta-analysis found that there is a positive correlation between the cumulative amount of first generation antipsychotics taken by people with schizophrenia and the amount of grey matter loss, and a negative correlation with the cumulative amount of second-generation antipsychotics taken. [63] [64]
Trifluoperazine, marketed under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia. [3] It may also be used short term in those with generalized anxiety disorder but is less preferred to benzodiazepines. [3] It is of the phenothiazine chemical class. It was approved for medical use in the ...
First generation antipsychotics are used to treat schizophrenia and are often accompanied by extrapyramidal side effects. [1] They inhibit dopaminergic neurotransmission in the brain by blocking about 72% of the D2 dopamine receptors. [15] They can also block noradrenergic, cholinergic, and histaminergic activity. [15]
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