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Sjögren's syndrome (SS) is the third-most common rheumatic autoimmune disorder, behind rheumatoid arthritis and systemic lupus erythematosus. [19] There are no geographical differences in the rates of SS. [97] Sjögren's syndrome has been reported in all areas of the world, although regional rates have not been well studied. [97] [98]
Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC conjugate. Anti-SSA autoantibodies (anti–Sjögren's-syndrome-related antigen A autoantibodies, also called anti-Ro, or similar names including anti-SSA/Ro, anti-Ro/SSA, anti–SS-A/Ro, and anti-Ro/SS-A) are a type of anti-nuclear autoantibodies that are associated with ...
20823 Ensembl ENSG00000138385 ENSMUSG00000068882 UniProt P05455 P32067 RefSeq (mRNA) NM_003142 NM_001294145 NM_001110145 NM_009278 NM_001355265 RefSeq (protein) NP_001281074 NP_003133 NP_001103615 NP_033304 NP_001342194 Location (UCSC) Chr 2: 169.79 – 169.81 Mb Chr 2: 69.69 – 69.7 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Sjögren syndrome type B antigen (SS-B) also known ...
In 70% of patients with rheumatoid arthritis, Felty's syndrome, Sjogren's syndrome, systemic sclerosis, and primary biliary cirrhosis, anti-histone antibodies are present. Anti-histone antibodies may also be present in Alzheimer's disease and dementia patients. [6]
Paraneoplastic syndrome, Guillain-Barré syndrome, diabetes, amyloidosis, Sjogren's syndrome, and Morvan syndrome. Autoimmune autonomic ganglionopathy is a type of immune-mediated autonomic failure that is associated with antibodies against the ganglionic nicotinic acetylcholine receptor present in sympathetic , parasympathetic , and enteric ...
21-hydroxylase antibodies Confirmed 0.93-1.4 per 10,000 [72] Autoimmune oophoritis: Ovaries: Anti-ovarian antibodies Probable Rare [73] Autoimmune orchitis: Testes: Anti-sperm antibodies Probable Rare [74] Autoimmune pancreatitis: Pancreas: IgG4, Anti-CA2 antibodies Confirmed 0.82-1.3 per 100,000 [75] Autoimmune polyendocrine syndrome type 1 (APS1)
Ianalumab (INN; [1] development code VAY736) is a monoclonal antibody that is being investigated for autoimmune hepatitis, multiple sclerosis, pemphigus vulgaris, rheumatoid arthritis, Sjögren syndrome, and systemic lupus erythematosus. [2] [3] [4] This drug is being developed by Novartis. In 2021 ianalumab was undergoing Phase II/III trials.
The mechanism of antibody production in Sjögren's syndrome is not fully understood, but apoptosis (programmed cell death) and molecular mimicry may play a role. [12] The Ro and La antigens are expressed on the surface of cells undergoing apoptosis and may cause the inflammation within the salivary gland by interaction with cells of the immune ...
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