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1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC, EDAC or EDCI) is a water-soluble carbodiimide usually handled as the hydrochloride. [1] It is typically employed in the 4.0-6.0 pH range. It is generally used as a carboxyl activating agent for the coupling of primary amines to yield amide bonds.
The acid 1 will react with the carbodiimide to produce the key intermediate: the O-acylisourea 2, which can be viewed as a carboxylic ester with an activated leaving group. The O-acylisourea will react with amines to give the desired amide 3 and urea 4. The possible reactions of the O-acylisourea 2 produce both desired and undesired products.
1 Science and technology. 2 Other uses. 3 See also. Toggle the table of contents. ... 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide, a water-soluble carbodiimide ...
1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, also known as EDC, is a water-soluble carbodiimide that exhibits similar reactivity as CMC, and is also used for the chemical probing of RNA structure. EDC is able to permeate into cells and is thus used for direct in-cell probing of RNA in their native environments.
A common way to synthesize an NHS-activated acid is to mix NHS with the desired carboxylic acid and a small amount of an organic base in an anhydrous solvent. A coupling reagent such as dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) is then added to form a highly reactive activated acid intermediate.
The death of Elijo Gonzalez, a 5-year-old who shot himself in early 2023, falls into that second category. The victim and his sister, 11, were being watched by their uncle, Bryan Jaensch, in a ...
They then get into the Los Angeles Dodgers signing Korean free agent Hyeseong Kim and the reason it’s a perfect landing spot for the three-time KBO Golden Glove Award winner. (3:07) - The Opener ...
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide This page was last edited on 7 September 2024, at 08:38 (UTC). Text is available under the Creative Commons ...