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The term variant of concern (VOC) for SARS-CoV-2, which causes COVID-19, is a category used for variants of the virus where mutations in their spike protein receptor binding domain (RBD) substantially increase binding affinity (e.g., N501Y) in RBD-hACE2 complex (genetic data), while also being linked to rapid spread in human populations ...
The timeline of the COVID-19 pandemic lists the articles containing the chronology and epidemiology of SARS-CoV-2, [1] the virus that causes the coronavirus disease 2019 and is responsible for the COVID-19 pandemic. The first human cases of COVID-19 occurred in Wuhan, People's Republic of China, on or about 17 November 2019. [2]
Before 24 February 2020, over 95% of all deaths from COVID-19 worldwide had occurred in Hubei province, where Wuhan is located. [183] [184] As of 10 March 2023, the percentage had decreased to 0.047%. [180] As of 10 March 2023, there were 676,609,955 total confirmed cases of SARS‑CoV‑2 infection. [180]
The Omicron variant features as such for the first time in the overview of WHO's weekly operational update, namely "Supporting Omicron variant detection and COVID-19 response in southern Africa." As of 2 December, Botswana and South Africa have reported 19 and 172 Omicron variant cases, respectively, accounting for 62% of global cases.
One way to estimate COVID-19 deaths that includes unconfirmed cases is to use the excess mortality, which is the overall number of deaths that exceed what would normally be expected. [4] From March 1, 2020, through the end of 2020, there were 522,368 excess deaths in the United States, or 22.9% more deaths than would have been expected in that ...
However, doctors say the updated COVID-19 vaccine is expected to help provide protection from this variant. The updated vaccine is based on the XBB.1.5, and HV.1 is a “grandchild” of the XBB.1 ...
JN.1 is a COVID-19 variant that descended from BA.2.86, explains infectious disease expert Amesh Adalja, M.D., a senior scholar at the Johns Hopkins Center for Health Security. JN.1 is “another ...
The spread of the JN.1 Omicron variant has led to a surge of COVID-19 cases in New Zealand, resulting in 400 hospitalisations per week and 25 deaths. [340] The JN.1 variant accounted for 14% of sequenced cases reported in New Zealand during the week leading up to 15 December.
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