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These neurons re-enter the cell cycle as they travel to the ganglion cell layer when they are activated by p75NTR. These neurons are unable to enter mitosis and are stuck in a 4C DNA content state. Cell cycle re-entry by p75NTR is not dependent on Cdk4/6 (Morillo et al., 2012) and, therefore, differs from other cell types that re-enter the cell ...
The nervous system is divided by neurologists into two parts: the central nervous system (which consists of the brain and spinal cord) and the peripheral nervous system (which consists of cranial and spinal nerves along with their associated ganglia). While the peripheral nervous system has an intrinsic ability for repair and regeneration, the ...
In the developing zebrafish spinal cord, early spontaneous activity is required for the formation of increasingly synchronous alternating bursts between ipsilateral and contralateral regions of the spinal cord and for the integration of new cells into the circuit. [63] Motor neurons innervating the same twitch muscle fibers are thought to ...
At a chemical synapse, one neuron releases neurotransmitter molecules into a small space (the synaptic cleft) that is adjacent to another neuron. The neurotransmitters are contained within small sacs called synaptic vesicles, and are released into the synaptic cleft by exocytosis.
Neurons vary in shape and size and can be classified by their morphology and function. [20] The anatomist Camillo Golgi grouped neurons into two types; type I with long axons used to move signals over long distances and type II with short axons, which can often be confused with dendrites. Type I cells can be further classified by the location ...
[20] [21] In fact, gap junctions facilitate the direct flow of electrical current without the need for neurotransmitters, as well as small molecules like calcium. [22] Thus, the main advantage of an electrical synapse is the rapid transfer of signals from one cell to the next. [20]
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In both images neurons are stained with a somatodendritic marker, microtubule associated protein (red). In the right image, synaptic vesicles are stained in green (yellow where the green and red overlap). Scale bar = 25 μm. [3] Synaptic vesicles are relatively simple because only a limited number of proteins fit into a sphere of 40 nm diameter.