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4-Hydroxyphenylpyruvate dioxygenase (HPPD) is an enzyme found in both plants and animals, which catalyzes the catabolism of the amino acid tyrosine. [4] Preventing the breakdown of tyrosine has three negative consequences: the excess of tyrosine stunts growth; the plant suffers oxidative damage due to lack of tocopherols (vitamin E); and ...
The mechanism of action of nitisinone involves inhibition of 4-Hydroxyphenylpyruvate dioxygenase (HPPD). [5] [6] This is a treatment for patients with Tyrosinemia type 1 as it prevents the formation of 4-Maleylacetoacetic acid and fumarylacetoacetic acid, which have the potential to be converted to succinyl acetone, a toxin that damages the liver and kidneys. [4]
4-Hydroxyphenylpyruvate dioxygenase (HPPD), also known as α-ketoisocaproate dioxygenase (KIC dioxygenase), is an Fe(II)-containing non-heme oxygenase that catalyzes the second reaction in the catabolism of tyrosine - the conversion of 4-hydroxyphenylpyruvate into homogentisate.
Mesotrione inhibits the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD). [3] It is an extremely potent inhibitor of HPPD in laboratory tests using the plant Arabidopsis thaliana, with a K i value of about 10 pM. [6] In plants, HPPD is necessary for the biosynthesis of tocopherols and of plastoquinone, which is essential to carotenoid production.
4-hydroxyphenylpyruvate dioxygenase, an enzyme found in almost all aerobic life forms and the primary target of some herbicides One of those HPPD inhibitor herbicides, a 4-hydroxyphenylpyruvate dioxygenase inhibitor
The United States Food and Drugs Administration is warning pet owners about a common medication given to pets to treat arthritis. The F.D.A. now says that the drug Librela may be associated with ...
In the mid-1980s, scientists at Stauffer Chemical Company published patents to benzoyl-substituted cyclohexanediones which led to their product mesotrione. [3] This encouraged workers at Rhône-Poulenc to expand their own research into molecules with the same mode of action as these 4-hydroxyphenylpyruvate dioxygenase inhibitors.
A demonic California dad has been arrested for allegedly beheading his 1-year-old son Friday in an early-morning frenzy of violence that also injured his wife and her mother, according to police.
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